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MINI-REVIEW

Transformative natural product-drug combinations: Advancing techniques to enhance efficacy against drug-resistant pathogens

Mathew Gideon1,2*
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1 Department of Environment, Ministry of Environment and Natural Resources, Kaduna, Nigeria
2 Department of Pure and Applied Chemistry, Faculty of Physical Sciences, Kaduna State University, Kaduna, Nigeria
INNOSC Theranostics and Pharmacological Sciences, 4068 https://doi.org/10.36922/itps.4068
Submitted: 28 June 2024 | Revised: 16 December 2024 | Accepted: 3 January 2025 | Published: 17 January 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

This review explores the development, modification, and optimization of potent active compounds using combinatorial synthetic methods that incorporate phytoconstituents from plant extracts, aiming to enhance efficacy and mitigate resistance. Attenuated total reflectance-Fourier transform infrared spectroscopy, gas chromatography-mass spectrometry (GC-MS), and antibacterial data from the literature were employed to validate these strategies. The methodology emphasized precise harvesting, pre-treatment, and extraction processes to ensure the quality and efficacy of the plant extracts. Various extraction methods and solvents were used to isolate specific phytoconstituents, followed by further purification through chromatography. The review proposes three strategies: (i) reacting single or multiple plant extracts with reagents such as acids or catalysts, (ii) combining plant extracts with ineffective drugs to induce structural changes that enhance antibacterial efficacy, and (iii) integrating plant extracts with drugs not originally intended for the target disease to explore new structural functionalities. Significant findings include synergistic effects observed when Psidium guajava and Calotropis procera extracts were combined with antibiotics, leading to substantially increased zones of inhibition against resistant bacteria. GC-MS analysis identified numerous bioactive compounds, some of which with known anticancer properties, suggesting potential applications beyond antibacterial effects. These innovative combinatorial approaches demonstrate the potential to yield new compounds with enhanced pharmacological properties, highlighting the critical role of plant extracts in drug discovery and development. This review underscores the promise of harnessing natural products to combat multi-drug resistance, paving the way for advanced research and development in pharmaceutical applications.

Keywords
Combinatorial synthetic methods
Phytoconstituents
Drug resistance
Plant extracts
Antimicrobial activity
Synergistic effects
Drug discovery and development
Funding
None.
Conflict of interest
The author declares no competing interests.
References
  1. Cesur S, Demiröz A. Antibiotics and the mechanisms of resistance to antibiotics. Med J Islamic World Acad Sci. 2013;21:138-142. doi: 10.12816/0002645

 

  1. Olga P, Blasco L, Bleriot I, et al. Strategies to combat multidrug-resistant and persistent infectious diseases. Antibiotics (Basel). 2020;9(2):65. doi: 10.3390/antibiotics9020065

 

  1. World Health Organization. Antimicrobial Resistance. Available from: https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance [Last assessed on 2023 May 13].

 

  1. UNEP - UN Environment Programme. Available from: https://www.unep.org/topics/chemicals-and-pollution-action/pollution-and-health/antimicrobial-resistance-global-threat [Last assessed on 2023 May 13].

 

  1. Nature. Antibiotic Resistance is a Growing Threat - Is Climate Change Making it Worse? Available from: https://www. nature.com/articles/d41586-023-04077-0 [Last assessed on 2023 May 13].

 

  1. American Society for Microbiology. Policy Pathways to Combat the Global Crisis of Antimicrobial Resistance. Available from: https://asm.org/getmedia/5f665383-881a- 493d-ae05-04a960a25548/amr-policy-paper-2023.pdf [Last assessed on 2023 May 13].

 

  1. Tong Y, Luo YF, Gao W. Biosynthesis of paclitaxel using synthetic biology. Phytochem Rev. 2022;21:863-877. doi: 10.1007/s11101-021-09766-0

 

  1. Wu YM, Liao QG, Shang Y, Gong ZP, Gou JB. Recent progress of paclitaxel biosynthesis aided by multi-omics. Plant Sci J. 2022;40(6):853-866. doi: 10.11913/PSJ.2095-0837.2022.60853

 

  1. Sati P, Sharma E, Dhyani P. Paclitaxel and its semi-synthetic derivatives: Comprehensive insights into chemical structure, mechanisms of action, and anticancer properties. Eur J Med Res. 2024;29(1):90. doi: 10.1186/s40001-024-01657-2

 

  1. Wang Z, Hui C. Contemporary advancements in the semi-synthesis of bioactive terpenoids and steroids. Org Biomol Chem. 2012;9:3791-3812. doi: 10.1039/D1OB00448D

 

  1. Newman DJ. Drug discovery from natural sources. Curr Pharmacol Rep. 2023;9:67-89. doi: 10.1007/s40495-023-00313-3

 

  1. Ribaudo G. Natural products chemistry: Advances in synthetic, analytical and bioactivity studies. Molecules. 2023;28(14):5577. doi: 10.3390/molecules28145577

 

  1. Julia MB, Fernando R, Purificación S, Ana MM, María JN, Agustin GA. Analysis and antioxidant capacity of anthocyanin pigments. Part I: General considerations concerning polyphenols and flavonoids. Crit Rev Anal Chem. 2012;42:102-125. doi: 10.1080/10408347.2011.632312

 

  1. Dixon D, Jeena, G. Comparison of different solvents for phytochemical extraction potential from Datura metel plant leaves. Int J Biol Chem. 2017;11:17-22. doi: 10.3923/ijbc.2017.17.22

 

  1. Truong DH, Nguyen DH, Anh Ta NT, Vo Bui A, Ha Do T, Nguyen HC. Evaluation of the use of different solvents for phytochemical constituents, antioxidants, and in vitro anti-inflammatory activities of Severinia buxifolia. J Food Qual. 2019;9:1-9. doi: 10.1155/2019/8178294

 

  1. Thomas J, Barley A, Willis S, Thomas J, Verghese M. Effect of different solvents on the extraction of phytochemicals in colored potatoes. Food Nutr Sci. 2020;11(10):942-954. doi: 10.4236/fns.2020.1110066

 

  1. Khosravi Z. Evaluating the efficacy of garlic and cranberry extracts against E. coli causing urinary tract infections. Biol Eng Med Sci Rep. 2021;6(2):22-27. doi: 10.5530/bems.6.2.7

 

  1. Alzohairy MA. Therapeutics role of Azadirachta indica (Neem) and their active constituents in diseases prevention and treatment. Evid Based Complement Alternat Med. 2016;2016:7382506. doi: 10.1155/2016/7382506

 

  1. Njobdi S, Gambo M, Ishaku GA. Antibacterial activity of Zingiber officinale on Escherichia coli and Staphylococcus aureus. J Adv Biol Biotechnol. 2018;19(1):1-8. doi: 10.9734/JABB/2018/43534

 

  1. Ashburn TT, Thor KB. Drug repositioning: Identifying and developing new uses for existing drugs. Nat Rev Drug Discov. 2004;3(8):673-683. doi: 10.1038/nrd1468

 

  1. Amgad MR. Potent toxic effects of Taroxaz-104 on the replication of SARS-CoV-2 particles. Chem Biol Interact. 2021;343:109480. doi: 10.1016/j.cbi.2021.109480

 

  1. Amgad MR, Mohnad A. Evaluation of a series of nucleoside analogs as effective anticoronaviral-2 drugs against the Omicron-B.1.1.529/BA.2 subvariant: A repurposing research study. Med Chem Res. 2023;32(2):326-341. doi: 10.1007/s00044-022-02970-3

 

  1. Khoddami A, Wilkes MA, Roberts TH. Techniques for analysis of plant phenolic compounds. Molecules. 2013;18(2):2328-2375. doi: 10.3390/molecules18022328

 

  1. Azwanida NN. A review on the extraction methods use in medicinal plants, principle, strength, and limitation. Med Aromat Plants. 2015;4(3):196. doi: 10.4172/2167-0412.1000196

 

  1. Salam AM, Lyles JT, Quavers CL. Methods in the extraction and chemical analysis of medicinal plants. Springer Protoc Handb. 2019. doi: 10.1007/978-1-4939-8919-5_17

 

  1. Gideon M. Novel strategy for optimizing the antibacterial activity of Psidium guajava against clinical isolates of Escherichia coli, Staphylococcus aureus, Salmonella spp., and Streptococcus spp. INNOSC Theranostics Pharmacol Sci. 2022;5:27-34. doi: 10.36922/itps.1131

 

  1. Brown TL, LeMay HE, Bursten BE, Murphy CJ. Chemistry: The Central Science. 14th ed. Boston: Pearson Education; 2017.

 

  1. Javed R, Zia M, Naz S, Aisida SO, Ul Ain N, Ao Q. Role of capping agents in the application of nanoparticles in biomedicine and environmental remediation: Recent trends and future prospects. J Nanobiotechnol. 2020;18(1):172. doi: 10.1186/s12951-020-00704-4

 

  1. Saddaf R, Muhammad A, Sabaz AK, Mohammad MS. Characterization and synergistic antibacterial potential of green synthesized silver nanoparticles using aqueous root extracts of important medicinal plants of Pakistan. Colloids Surf B Biointerface. 2019;179:317-325. doi: 10.1016/j.colsurfb.2019.04.016

 

  1. Gideon M, Ladan Z. Synergistic combinatorial strategy for combating antimicrobial resistance (AMR) in clinical bacteria by combining antibiotics with plant extracts. Fine Chem Eng. 2023;4:1-12. doi: 10.37256/fce.4120232071

 

  1. Eze EA, Oruche NE, Eze CN. Interaction of the extracts of three medicinal plants with antibiotics against some antibiotic-resistant bacteria. Sci Res Essays. 2013;8(28): 1360-1367. doi: 10.5897/SRE2013.5515

 

  1. Moussaoui F, Alaoui T. Evaluation of antibacterial activity and synergistic effect between antibiotic and the essential oils of some medicinal plants. Asian Pac J Trop Biomed. 2016;6(1):32-37. doi: 10.1016/j.apjtb.2015.09.024

 

  1. Haq A, Maleeha S, Syeda ZB, et al. A comprehensive investigation on the synergistic antibacterial activities of Jatropha curcas pressed cake and seed oil in combination with antibiotics. AMB Express. 2019;9(1):67. doi: 10.1186/s13568-019-0793-6

 

  1. Gideon M, Ladan Z, Yakubu Y. Acid induced phytoconstituents of Calotropis procera Extract combined with ampicillin in combating clinical resistant isolates of Staphylococcus aureus and Salmonella spp. Fine Chem Eng. 2024;5:111-122. doi: 10.37256/fce.5120244088

 

  1. Young YJ, Sun T, Gautam S, Lu F, Frank A, Kwang SA. Potential anti-inflammatory and anti-cancer properties of farnesol. Molecules. 2018;23(11):2827. doi: 10.3390/molecules23112827

 

  1. BIOSYNTH. 4-Amino-1-Pentanol - FA17418. Available from: https://www.biosynth.com/p/FA17418/927-55-9-4- amino-1-pentanol [Last accessed 2023 Aug 28].

 

  1. Amita V, Sunil J, Deepika S. Imidazole: Having versatile biological activities. J Chem. 2013;2013(2):329412. doi: 10.1155/2013/329412

 

  1. Siswadi S, Grace SS. Phytochemical analysis of bioactive compounds in ethanolic extract of Sterculia quadrifida R. Br. AIP Conf Proc. 2021;2353:030098. doi: 10.1063/5.0053057

 

  1. Gideon M, Ladan Z, Duniya EK, James MA, Dennis S. Stimulating antimicrobial activity in aspirin with Psidium guajava and Syzygium aromaticum extracts against multi-drug resistant Salmonella spp.: A comparative study of multiple combinations. Fine Chem Eng. 2023;4:46-57. doi: 10.37256/fce.4120232370
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INNOSC Theranostics and Pharmacological Sciences, Electronic ISSN: 2705-0823 Print ISSN: 2705-0734, Published by AccScience Publishing
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