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With the rapid development of different disciplines, we have set up Column to deeply explore, comprehensively report, and focus on highly innovative and highly academically valuable scientific research results in the research fields covered by each journal. Column brings together the best topics selected by the Editor-in-Chief’s and Editorial Board’s teams based on the future academic trends and the latest research hotspots of different disciplines around the world to publish high-quality scientific research and academic results after soliciting contributions and rigorous peer review.
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Tumor Microenvironment (TME)
Summary: Tumor microenvironment is essential to the formation of relevant tumors. Recent evidence showed that tumor microenvironment (TME) is essential for regulating immune escape, drug resistance, progression and metastasis of malignant cells. Moreover, the tumor microenvironment is known to be involved in acquired resistance of tumors to various therapies. The tumor microenvironment assists tumor growth by providing diverse structural, immunological, and nutritional support. It can also serve as a barrier to effective cancer treatments or facilitate the development of tumor drug resistance. The tumor microenvironment includes non-cancerous cells in the tumor and proteins expressed by them that contribute to tumor growth. Increasing evidence suggests that the tumor microenvironment is a critical factor inducing cancer therapeutic resistance.
Release date: 2024
Epigenetics: Definition, Mechanisms
Summary: Epigenetics is the study of non-genotoxic, reversible, heritable changes in a gene's phenotype due to processes that occur without changing the underlying DNA sequence. The two best understood epigenetic mechanisms include DNA methylation and histone modifications, but some recent advancements have been made to discover other processes such as noncoding RNA and prions that are impacted by epigenetics. Some of the disorders associated with anomalous epigenetics include cancer, Rett syndrome, Prader-Willi syndrome (PWS), Angelman syndrome, and BWS.   One of the most significant topics regarding epigenetics includes transgenerational inheritance as there are imprint control areas and transposable elements at which parental epigenetic marks are not erased.
Release date: 2024
Biomedical Science for Healthcare Informatics
Summary: Biomedical science focuses on how cells, organs and systems function in the human body; an exciting and dynamic area that is highly relevant to the understanding and treatment of human diseases. With the rapid development of computer software and hardware technologies, more and more healthcare data are becoming readily available from clinical institutions, patients, insurance companies, and pharmaceutical industries, among others. This access provides an unprecedented opportunity for data science technologies to derive data-driven insights and improve the quality of care delivery. In particular, we summarize the general solutions to the statistical challenges, system challenges, and privacy issues in federated learning, and point out the implications and potentials in healthcare. 
Release date: 2024
Behavioral Addiction
Summary: Behavioral addiction is a form of addiction that involves a compulsion to engage in a rewarding non-substance -related behavior – sometimes called a natural reward – despite any negative consequences to the person's physical, mental, social or financial well-being. Addiction canonically refers to substance abuse; however, the term's connotation has been expanded to include behaviors that may lead to a reward (such as gambling, eating, or shopping) since the 1990s. A number of dopaminergic genes such as the dopamine D2 receptor gene polymorphisms as well as other dopaminergic regulator  gene transcription factors like  ΔFosB has been identified as a necessary common factor involved in both behavioral and drug addictions, which are associated with the same neurochemical mechanisms and neuroadaptations in the reward system involving reward deficiency or even adolescent neurodevelopmental reward sufficiency or high dopaminergic function may load onto aberrant unwanting seeking behavior.     
Release date: 2023
Enviromental and Epigenetic Impact and Health Development in Pharmacological Research
Summary: Environmental science is an interdisciplinary that integrates biology, physics and geography (including zoology, chemistry, plant science,oceanology, geology, ecology, mineralogy, even atmospheric science to the study of the environment, and the solution of environmental problems. Environmental science emerged from the fields of natural history and medicine including forensics. Currently, it provides an integrated, quantitative, and interdisciplinary approach to the investigation of environmental systems. It is now known that in the field of medicine most environmental events can be impacted by epigenetics. In biology , epigenetics is the study of stable changes in cell function (known as marks) that do not involve alterations in theDNA sequence. The Greek prefix epi- (ἐπι- "over, outside of, around") in epigenetics implies features that are "on top of" or "in addition to" the traditional genetic basis for inheritance. Epigenetics most often involves changes that affect the regulation of gene expression, and that persist through cellular division up to at least two generations. Such effects on cellular and phenotypic traits may result from external or environmental factors, or be part of normal development. It can also lead to diseases such as cancer, psychosis, and even reward deficiency or addiction liability.
Release date: 2023
Burning Mouth Syndrome
Summary: Burning mouth syndrome (BMS) is a burning, tingling or scalding sensation in the mouth, lasting for at least four to six months, with no underlying known dental or medical cause. No related SIGNS OF THE DISEASE  are found in the mouth. People with burning mouth syndrome may also have a subjective XEROSTOMIA ,PARAESTHESIA or an altered sense of taste or smell. The International Association for the Study of Pain defines burning mouth syndrome as "a distinctive nosological entity characterized by unremitting oral burning or similar pain in the absence of detectable mucosal  changes"[  and "burning pain in the tongue or other oral mucous membranes", and the international Headache Society defines it as "an intra-oral burning sensation for which no medical or dental cause can be found". To ensure the correct diagnosis of burning mouth syndrome, Research Diagnostic Criteria (RDC/BMS) have been developed.Insufficient evidence leaves it unclear if effective treatments exist. For this special issue we are very interested in studies dealing with the physiological mechanisms involved and any novel treatments.  
Release date: 2023
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INNOSC Theranostics and Pharmacological Sciences, Electronic ISSN: 2705-0823 Published by AccScience Publishing