AccScience Publishing / ITPS / Online First / DOI: 10.36922/itps.4607
CASE REPORT

Managing atropine-induced psychosis in organophosphate poisoning: A case report

Mohammed Misbah Ul Haq1* Juveria Almas1 Soha Amreen1 Mohammed Zabeeruddin1
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1 Department of Pharmacy Practice, Deccan School of Pharmacy, Hyderabad, Telangana, India
INNOSC Theranostics and Pharmacological Sciences 2024, 7(4), 4607 https://doi.org/10.36922/itps.4607
Submitted: 21 August 2024 | Accepted: 10 October 2024 | Published: 30 October 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Atropine-induced psychosis, though rare, is a critical adverse effect that can arise during the treatment of organophosphate (OP) poisoning, necessitating swift recognition for optimal patient care. This case report describes the presentation of a 45-year-old male with a history of chronic alcoholism and smoking, admitted for OP intoxication, who developed acute psychosis after atropine administration. The symptoms included hallucinations, agitation, and delirium, with diagnostic evaluation confirming atropine-induced psychosis according to DSM-IV-TR criteria. The treatment approach involved discontinuing atropine and providing supportive care, which resulted in symptom resolution within several days. In addition, benzodiazepines were administered to manage agitation and anxiety. This case highlights the need for careful monitoring of drug reactions, particularly in patients with risk factors, such as chronic alcoholism. It underscores the importance of individualized treatment strategies and the critical role of healthcare professionals in recognizing and addressing atropine-induced psychosis. Further research is warranted to better understand the underlying mechanisms and risk factors associated with this complication.

Keywords
Atropine-induced psychosis
Organophosphate poisoning
Adverse drug reactions
Psychiatric manifestations
Management strategies
Funding
None.
Conflict of interest
Dr. Mohammed Misbah Ul Haq is an Editorial Board Member of this journal, but was not in any way involved in the editorial and peer-review process conducted for this paper, directly or indirectly. Separately, other authors declared that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.
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INNOSC Theranostics and Pharmacological Sciences, Electronic ISSN: 2705-0823 Print ISSN: 2705-0734, Published by AccScience Publishing