AccScience Publishing / ITPS / Volume 7 / Issue 1 / DOI: 10.36922/itps.1388
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REVIEW

Cytotoxicity of bioactive compounds derived from cyanobacteria

Hanaa Ali Hussein1* Fatin L. Khaphi1 Zahra Kadhum Saeed1
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1 Department of Basic Sciences, College of Dentistry, University of Basrah, Basrah, Iraq
INNOSC Theranostics and Pharmacological Sciences 2024, 7(1), 1388 https://doi.org/10.36922/itps.1388
Submitted: 27 July 2023 | Accepted: 5 September 2023 | Published: 26 October 2023
© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

Cyanobacteria are rich in bioactive compounds that exhibit diverse biological activities, including antiproliferative, cytotoxic, and antineoplastic properties. Many of these compounds are currently being studied in clinical trials. In this paper, newly discovered bioactive compounds from various cyanobacteria species that have demonstrated anticancer effects against multiple cancer cell lines, such as apratoxin, symplostatin 1, bartolosides, caylobolide, bisebromoamides, carmaphycins, and anaenamides, are reviewed. At present, there are no clear guidelines on approving cyanobacteria-derived bioactive compounds for use in treating diseases. While it is not uncommon that the intake of these compounds is accompanied by side effects, investigations on these compounds should focus on increasing the safety and efficacy of the compounds, or at least tread a fine line between drug safety and effectiveness for cancer patients. This review overviews the efficacy and cytotoxicity of cyanobacteria-derived bioactive compounds, providing researchers insights into how to maximize the benefits of these compounds through research.

Keywords
Bioactive compounds
Cyanobacteria
Cytotoxicity
Funding
None.
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Conflict of interest
The authors declare that they have no competing interests.
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INNOSC Theranostics and Pharmacological Sciences, Electronic ISSN: 2705-0823 Published by AccScience Publishing