AccScience Publishing / ITPS / Volume 4 / Issue 2 / DOI: 10.36922/itps.v4i2.43

Role of Insulin in Brain: An Emphasis on Molecular Functions

Snehashis Kundu1 Sayeed Mohammed Firdous2
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1 National Institute of Pharmaceutical Education and Research Guwahati, Changsari, Assam, India
2 Department of Pharmacology, Calcutta Institute of Pharmaceutical Technology and AHS, Howrah, West Bengal, India
INNOSC Theranostics and Pharmacological Sciences 2021, 4(2), 17–21;
Submitted: 8 March 2022 | Accepted: 23 May 2022 | Published: 30 June 2022
© 2022 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( )

Insulin signaling in brain has emerged as a recent field of research since decreased brain insulin levels were linked to impaired learning, memory, and neurodegenerative diseases like Alzheimer’s disease. Brain insulin has a pivotal role in regulating glucose metabolism, memory, learning, neuron formation, and to be neuroprotective through a cascade of cellular signaling process. In addition, insulin may serve as a promising therapy against diabetes and neurodegeneration conditions. Interestingly, insulin has been also faced as the potential missing link between neurodegenerative disorders and diabetes. Therefore, this review aims to untangle the complex interactions among aging and diabetes which allow the development of more effective therapeutic strategies to conquer neurodegenerative condition as well as diabetes.

Neurodegenerative diseases

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Conflict of interest
No conflict of interest declared.
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INNOSC Theranostics and Pharmacological Sciences, Electronic ISSN: 2705-0823 Published by AccScience Publishing