AccScience Publishing / ITPS / Volume 2 / Issue 2 / DOI: 10.36922/itps.v2i2.904
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RESEARCH ARTICLE

Long-term Administration of Lovastatin and Rivastigmine: An In Vivo Evaluation on Cognitive Functions and Brain Acetylcholinesterase Activity

Badruddeen 11 Juber Akhtar* Muhammad Arif1 Mohammad Irfan Khan1 Md. Mujahid1 Mohammad Ahmad1
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1 Faculty of Pharmacy, Integral University, Lucknow 226026, India
INNOSC Theranostics and Pharmacological Sciences 2019, 2(2), 904 https://doi.org/10.36922/itps.v2i2.904
Submitted: 1 May 2019 | Accepted: 21 February 2020 | Published: 26 February 2020
© 2020 by the Authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

Background. There is not much evidence illustrating that statins could be responsible for memory loss or dementia, although increased exposure to statins has been reported to cause cognitive side effects. The present study investigated the effect of lovastatin in combination with rivastigmine on cognitive function as well as brain acetylcholinesterase (AChE) activity in normal mice.
Methods. The mice were categorized into four groups, and they were treated with normal saline, lovastatin, rivastigmine, and the combination of lovastatin and rivastigmine, respectively, by oral administration for 60 days. The treatment effect on cognitive functions was assessed by behavioral tests, namely, the passive avoidance test and spontaneous alternation test, as well as the measurement of brain AChE activity by Ellman’s method.
Results. In this study, a significant reduction (P < 0.01) of brain AChE activity and positive effects (P < 0.01) on cognitive 
functions was observed in mice treated with the combination of lovastatin and rivastigmine as compared to rivastigmine alone. However, no significant differences (P < 0.05) were observed on brain AChE activity as well as cognitive functions in mice treated with lovastatin when compared with those treated with normal saline.
Conclusion. This study suggested that lovastatin did not contribute to any improvements in cognitive functions and brain AChE activity, but it potentiated the effect of rivastigmine.

Keywords
Lovastatin
Rivastigmine
Cognition
Behavioral
Brain acetylcholinesterase activity
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Conflict of interest
The authors have no conflicts of interest.
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INNOSC Theranostics and Pharmacological Sciences, Electronic ISSN: 2705-0823 Published by AccScience Publishing