AccScience Publishing / ITPS / Volume 2 / Issue 2 / DOI: 10.36922/itps.v2i2.775
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REVIEW

In vitro and In vivo Models for Anti-inflammation: An Evaluative Review

Fabian Ifeanyi Eze1* Philip F. Uzor1 Peter Ikechukwu2 Bonaventure C. Obi2 Patience O. Osadebe1*
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1 Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria Nsukka, 410001, Nigeria
2 Department of Pharmacology and Toxicology, University of Nigeria Nsukka, 410001, Nigeria
INNOSC Theranostics and Pharmacological Sciences 2019, 2(2), 755 https://doi.org/10.36922/itps.v2i2.775
Submitted: 22 June 2019 | Accepted: 8 October 2019 | Published: 22 November 2019
© 2019 by the Authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

Anti-inflammatory activity study involves developing a model that mimics, or provokes the production or release of, the 
biochemical mediators of inflammation, and monitoring the response of these biochemicals to the test drugs. This report constitutes an updated review of the in vitro and in vivo study models for assessing anti-inflammatory activity in plant extracts and synthetic drugs. The materials, instrumentation, and methods involved, as well as the mechanism of anti-inflammatory activity tested in each model, are extensively described. The merits and limitations of each method have also been discussed. A comparative assessment of the in vivo animal models vis-à-vis, the in vitro enzyme models have been made to assist scientists and researchers in the choice of assay method in terms of sensitivity, reliability, duration of test, ethical, and cost considerations.

Keywords
Anti-inflammatory activity
In vitro models
In vivo models
Inflammation
Prostaglandins
Arthritis
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Conflict of interest
All the authors have no conflicts of interest to declare.
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INNOSC Theranostics and Pharmacological Sciences, Electronic ISSN: 2705-0823 Published by AccScience Publishing