AccScience Publishing / ITPS / Volume 1 / Issue 1 / DOI: 10.26689/itps.v1i1.440
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Supplementation of Carrot Incorporated Paneer Attenuates Diabetes through its Antioxidant Potential in Streptozotocin-Nicotinamide-Induced Diabetic Rats

P. R. Nivedha Nivedha1 * V. V. Sathibabu Uddandrao1 * Ganapathy Saravanan1 * P. Brahmanaidu2 S. Vadivukkarasi1
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1 Department of Biochemistry, K. S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode, Tamil Nadu, India
2 Animal Physiology and Biochemistry Laboratory, ICMR-National Animal Resource Facility for Biomedical Research (NARFBR), Hyderabad, Telangana, India

*These authors contributed equally to this work.

INNOSC Theranostics and Pharmacological Sciences 2018, 1(1), 440
Submitted: 12 November 2018 | Accepted: 19 November 2018 | Published: 4 December 2018
© 2018 by the Authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( )

Background: The ideal medications for diabetes mellitus (DM) should have less or no adverse effects, thus screening 
on the antidiabetic activities of plant-based products is in urgent need. Paneer is the fundamental nutritious and complete native dairy products, and natural products incorporated paneer has greatly increased its therapeutic potential.
Objective: The current study was undertaken to explore the effects of carrot incorporated paneer (CIP) on blood glucose, body weight, insulin, and enzymatic antioxidants such as superoxide dismutase, catalase, glutathione (GSH) peroxidase, and reduced GSH in streptozotocin (STZ) and nicotinamide (NAD)-induced diabetes in rats.
Materials and Methods: Diabetic rats were orally supplemented with CIP (200 mg/kg body weight/day) for 1 month and the effects were compared with gliclazide (5 mg/kg body weight/day).
Results: Supplementation of CIP or gliclazide was resulted in noteworthy diminish in the levels of blood glucose and increase in body weight and insulin levels. STZ-NAD administration caused the diminution in enzymatic antioxidant activities in diabetic rats and supplementation with CIP predominantly enhanced the levels of antioxidant enzymes in diabetic rats when contrasted to diabetic group.
Conclusion: Hence, the results suggested that CIP has the potential antioxidant capability and may be believed as an efficient curative constituent for the management of DM.

Carrot incorporated paneer
diabetes mellitus
natural products
metabolic disorders

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Conflict of interest
The study was self-financed and authors declare no conflict with any individual or organization.
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INNOSC Theranostics and Pharmacological Sciences, Electronic ISSN: 2705-0823 Published by AccScience Publishing