AccScience Publishing / IMO / Online First / DOI: 10.36922/IMO026030002
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ORIGINAL RESEARCH ARTICLE

Innovative dental mineral trioxide aggregate composition based on a nanostructured calcium phosphate biomimetic filler

Igor Aleksandrovich Tarasov1 ,  Mikhail Aleksandrovich Trubitsyn1* ,  Lyubov Vladimirovna Furda1
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1 Department of General Chemistry, Institute of Pharmacy, Chemistry and Biology, Belgorod State National Research University, Belgorod, Belgorod Oblast, Russia
IMO, 026030002 https://doi.org/10.36922/IMO026030002
Received: 13 January 2026 | Revised: 8 February 2026 | Accepted: 28 February 2026 | Published online: 8 May 2026
© 2026 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
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Abstract

Mineral trioxide aggregate (MTA)-based dental materials are widely used in endodontic therapy due to their favorable sealing ability, biocompatibility, and bioactivity; however, ongoing research seeks to enhance their functional performance and biological responses by incorporating advanced biomimetic and nanostructured fillers. This study reports the development and comprehensive characterization of a novel MTA-type dental material based on a nanostructured calcium phosphate biomimetic filler. The base MTA was obtained from synthesized dental cement and commercial bismuth oxide, which served as the radiopacifier. To obtain the biomimetic obturating composition (BOC), base MTA was mixed with biomimetic filler consisting of nanostructured calcium-deficient, silicon- and fluorine-substituted hydroxyapatite synthesized using the authors’ methodology. Structural-morphological and physicochemical characteristics of all components were investigated using X-ray diffraction, Fourier-transform infrared spectroscopy, and scanning and transmission electron microscopy. In accordance with International Organization for Standardization (ISO) 6876:1986 requirements, key functional properties of BOC samples, such as flowability (20–23 mm), working time (630–660 s), setting time (420–680 s), radiopacity (>3 mmAl), and solubility (1.6–2.1%) were studied. In vitro bioactivity of BOC samples was evaluated through calcium ion release in simulated body fluid (SBF) and acetate buffer, as well as apatite-forming ability in SBF. It was found that incorporating the nanostructured biomimetic filler significantly enhanced calcium ion release and promoted the formation of a surface apatite layer, the thickness of which increased with filler content. The results demonstrate that the proposed BOC exhibits improved bioactivity while maintaining acceptable physicochemical and functional characteristics, indicating its potential for dental application.

Keywords
Dental materials
Mineral trioxide aggregate
Biomimetic hydroxyapatite
Calcium phosphate
Sol-gel synthesis
Bioresorbability
Funding
None.
Conflict of interest
The authors declare they have no competing interests.
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Innovative Medicines & Omics, Electronic ISSN: 3060-8740 Print ISSN: 3060-8910, Published by AccScience Publishing
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