AccScience Publishing / GTM / Online First / DOI: 10.36922/GTM025130032
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ORIGINAL RESEARCH ARTICLE

Antihypertensive prescription pattern and determinants of blood pressure control among chronic kidney disease patients

Oluwaseye M. Oladimeji1 ,  Adeola O. Ajibare1,2* ,  Oluwafemi T. Ojo1,2 ,  Tomiwa Sotubo1 ,  Akinola O. Dada1,2 ,  Ayoola Odeyemi1 ,  Adebowale O. Adekoya1,2 ,  Adelanke L. Arowolo3 ,  Abdulsalam O. Yusuf4 ,  Yusuf O. Oladosu5
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1 Department of Medicine, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria
2 Department of Medicine, Faculty of Clinical Sciences, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria
3 Department of Medicine, Gbagada General Hospital, Gbagada, Lagos, Nigeria
4 Salford Royal NHS Foundation Trust, Salford, Greater Manchester, United Kingdom
5 Department of Medicine, Military Hospital, Yaba, Lagos, Nigeria
Global Translational Medicine, 025130032 https://doi.org/10.36922/GTM025130032
Received: 27 March 2025 | Revised: 12 July 2025 | Accepted: 17 October 2025 | Published online: 13 November 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Hypertension is associated with an increased rate of progression of chronic kidney disease (CKD) to end-stage renal disease. It predicts mortality and adverse cardiovascular outcomes in both pre-dialysis CKD patients and those on renal replacement therapy. Thus, judicious use of antihypertensives and good blood pressure (BP) control may reduce morbidity and mortality among these patients. This study aims to assess the determinants of BP control and antihypertensive drug use patterns in CKD patients. A cross-sectional analytical study was conducted among CKD patients presenting to Lagos State University Teaching Hospital between April 2023 and January 2024. Recruited patients were classified into CKD stages 3–5, based on the estimated glomerular filtration rate. Clinical data were collected using a structured, interviewer-administered questionnaire. A total of 163 CKD patients were recruited into this study with a mean age of 54.04 ± 14.47 years. A history of hypertension and diabetes was found in 85.9% and 26.4% of the recruited patients, respectively. Poor BP control was observed in 50% of the subjects. Calcium channel blockers were the most frequently prescribed antihypertensive medications across CKD stages (p=0.046), while anemia and elevated serum creatinine levels were associated with poor BP control. These findings emphasize the importance of addressing anemia and elevated serum creatinine levels in the management of CKD patients.

Keywords
Chronic kidney disease
Hypertension
Blood pressure control
Antihypertensives
Funding
None.
Conflict of interest
The authors declare that they have no competing interests.
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Global Translational Medicine, Electronic ISSN: 2811-0021 Print ISSN: 3060-8600, Published by AccScience Publishing
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