Bridging the gap between guidelines and clinical practice: Physician management patterns of postherpetic neuralgia in the Tabuk region, Saudi Arabia
Introduction: Postherpetic neuralgia (PHN) is a chronic neuropathic pain condition following herpes zoster. Despite established guidelines, real-world management patterns remain poorly defined in Saudi Arabia.
Objective: To assess physician involvement, treatment practices, and perceived barriers in PHN management in the Tabuk region.
Methods: A cross-sectional survey was conducted among 113 physicians from multiple specialties. The questionnaire evaluated clinical involvement, use of pharmacologic and topical therapies, referral patterns, and psychosocial assessment practices. Descriptive statistics and categorical tests were applied.
Results: Only 36.3% of physicians reported routine involvement in PHN care, with significant variation across specialties (p < 0.001). Participation was highest among pain/palliative specialists (85.7%), neurologists (66.7%), and dermatologists (47.1%). Awareness of topical therapies was high (92.9%), but clinical use was lower (68.3%). Gabapentinoids (87.8%), tricyclic antidepressants (73.2%), and opioids (63.4%) were commonly prescribed. Key barriers included inefficient referral systems (70.7%), limited access to interventional procedures (68.3%), and lack of standardized protocols (61.0%). Although 95.1% recognized PHN’s quality-of-life impact, only 39.0% routinely assessed psychosocial burden.
Conclusions: PHN management in Tabuk shows limited physician involvement and systemic barriers. Despite high awareness of guidelines, implementation gaps persist, particularly in the use of topical therapy and psychosocial care. Strengthening referral systems and multidisciplinary approaches may improve care delivery.
- Johnson RW, Rice ASC. Postherpetic neuralgia. N Engl J Med. 2014;371(16):1526-1533. doi: 10.1056/NEJMcp1403062
- Johnson RW. Herpes zoster and postherpetic neuralgia: optimal treatment. Drugs Aging. 1997;10(2):80-94. doi: 10.2165/00002512-199710020-00002
- Dworkin RH, Portenoy RK. Pain and its persistence in herpes zoster. Pain. 1996;67(2):241-251. doi: 10.1016/0304-3959(96)03122-3
- Rice ASC, Maton S. Gabapentin in postherpetic neuralgia: a randomized, double-blind, placebo-controlled study. Pain. 2001;94(2):215-224. doi: 10.1016/S0304-3959(01)00407-9
- Schmader KE. Epidemiology and Impact on Quality of Life of Postherpetic Neuralgia and Painful Diabetic Neuropathy. Clin J Pain. 2002;18(6):350-354. doi: 10.1097/00002508-200211000-00002
- Turk DC, Dworkin RH, Allen RR, et al. Core outcome domains for chronic pain clinical trials: IMMPACT recommendations. Pain. 2003;106(3):337-345. doi: 10.1016/j.pain.2003.08.001
- Schmader KE. Herpes zoster. Ann Intern Med. 2018;169(3):ITC19-ITC31. doi: 10.7326/aitc201808070
- Oxman MN. Zoster vaccine: current status and future prospects. Clin Infect Dis. 2010;51(2):197-213. doi: 10.1086/653605
- Johnson RW, Bouhassira D, Kassianos G, et al. The impact of herpes zoster and postherpetic neuralgia on quality of life. BMC Med. 2010;8(1):37. doi: 10.1186/1741-7015-8-37
- Dworkin RH, Johnson RW, Breuer J, et al. Recommendations for the management of herpes zoster. Clin Infect Dis. 2007;44(Suppl 1):S1-S26. doi: 10.1086/510206
- Schmader KE, Johnson GR, Saddier P, et al. Effect of a Zoster Vaccine on Herpes Zoster–Related Interference with Functional Status and Health‐Related Quality‐of‐Life Measures in Older Adults. J Am Geriatr Soc. 2010;58(9):1634- 1641. doi: 10.1111/j.1532-5415.2010.03021.x
- Costigan M, Scholz J, Woolf CJ. Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci. 2009;32:1-32. doi: 10.1146/annurev.neuro.051508.135531
- Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011;152(3):S2-S15. doi: 10.1016/j.pain.2010.09.030
- Attal N, Cruccu G, Baron R, et al. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol. 2010;17(9):1113-e88. doi: 10.1111/j.1468-1331.2010.02999.x
- Hempenstall K, Nurmikko TJ, Johnson RW, et al. Analgesic therapy in postherpetic neuralgia: a quantitative systematic review. PLoS Med. 2005;2(7):e164. doi: 10.1371/journal.pmed.0020164
- Dworkin RH, O’Connor AB, Audette J, et al. Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. Mayo Clin Proc. 2010;85(3):S3-S14. doi: 10.4065/mcp.2009.0649
- Rowbotham M, Harden N, Stacey B, et al. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. JAMA. 1998;280(21):1837-1842. doi: 10.1001/jama.280.21.1837
- Watson CP, Vernich L, Chipman M, Reed K. Nortriptyline versus amitriptyline in postherpetic neuralgia. Neurology. 1998;51(4):1166-1171. doi: 10.1212/WNL.51.4.1166
- Backonja M, Wallace MS, Blonsky ER, et al. NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomized, double-blind study. Lancet Neurol. 2008;7(12):1106-1112. doi: 10.1016/S1474-4422(08)70228-X
- Dworkin RH, O’Connor AB, Backonja M, et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain. 2007;132(3):237-251. doi: 10.1016/j.pain.2007.08.033
- Moria HA. Cooling the burn: EMLA alone vs paravertebral block plus EMLA for improving tolerability of 8% capsaicin patch application in thoracic postherpetic neuralgia—a retrospective cohort study. Front Aging Neurosci. 2026;18:1762229. doi: 10.3389/fnagi.2026.1762229
- Gudin J, Fudin J, Wang E, Haylon T, Patel K, Goss TF. Treatment patterns and medication use in patients with postherpetic neuralgia. J Manag Care Spec Pharm. 2019;25(12):1387-1396. doi: 10.18553/jmcp.2019.19093
- Tang J, Zhang Y, Liu C, et al. Therapeutic Strategies for Postherpetic Neuralgia: Mechanisms, Treatments, and Perspectives. Curr Pain Headache Rep. 2023;27:307-319. doi: 10.1007/s11916-023-01146-x
- Hadley GR, Gayle JA, Ripoll J, et al. Post-herpetic neuralgia: a review. Curr Pain Headache Rep. 2016;20(3):17. doi: 10.1007/s11916-016-0548-x
- Mallick-Tearle S, Snodgrass B, Brant JM. Postherpetic neuralgia: epidemiology, pathophysiology, and pain management pharmacology. J Multidiscip Healthc. 2016;9:447-454. doi: 10.2147/JMDH.S106340
- Shrestha M, Chen Y. Modalities in managing postherpetic neuralgia. Korean J Pain. 2018;31(4):235-243. doi: 10.3344/kjp.2018.31.4.235
- Ellerbroek H, Kalkman GA, Kramers C, et al. Pharmacological strategies to decrease long-term prescription opioid use: a systematic review. J Clin Med. 2024;13(24):7770. doi: 10.3390/jcm13247770
- Chou R, Fanciullo GJ, Fine PG, et al. Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J Pain. 2009;10(2):113-130. doi: 10.1016/j.jpain.2008.10.008
- van Wijck AJM, Wallace M, Mekhail N, van Kleef M. Herpes zoster and post‐herpetic neuralgia. Pain Pract. 2011;11(1):88-97. doi: 10.1111/j.1533-2500.2010.00428.x
- Makharita NA, Amr YM, El-Bayoumy Y. Effect of early stellate ganglion blockade for facial pain from acute herpes zoster and incidence of postherpetic neuralgia. Pain Physician. 2012;15(6):467-474.
- Oguchi M, Nicholas MK, Asghari A, et al. Psychologically based interventions for adults with chronic neuropathic pain: a scoping review. Pain Med. 2024;25(6):400-414. doi: 10.1093/pm/pnae006
- Kovačević I, Pavić J, Filipović B, et al. Integrated approach to chronic pain—the role of psychosocial factors and multidisciplinary treatment: a narrative review. Int J Environ Res Public Health. 2024;21(9):1135. doi: 10.3390/ijerph21091135
- Kaye AD, Armistead G, Amedio LS, et al. Evolving treatment strategies for neuropathic pain: a narrative review. Medicina (Kaunas). 2025;61(6):1063. doi: 10.3390/medicina61061063
- Jung HY, Park HJ. Pain Management of Herpes Zoster. In: Pain Management. Rijeka, Croatia: InTech; 2016. doi: 10.5772/62873
- Chen W, Cheng Y, Cai Y, Hong J. Development of an evidence-based pain management protocol and its application in patients with postherpetic neuralgia. Medicine (Baltimore). 2025;104(51):e46629. doi: 10.1097/MD.0000000000046629
- Clopper CJ, Pearson ES. The use of confidence or fiducial limits illustrated in the case of the binomial. Biometrika. 1934;26(4):404-413. doi: 10.1093/biomet/26.4.404
- McNemar Q. Note on the sampling error of the difference between correlated proportions or percentages. Psychometrika. 1947;12(2):153-157. doi: 10.1007/BF02295996
- von Elm E, Altman DG, Egger M, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007;370(9596):1453-1457. doi: 10.1016/S0140-6736(07)61602-X
- Aggarwal A, Suresh V, Gupta B, Sonthalia S. Post-herpetic neuralgia: a systematic review of current interventional pain management strategies. J Cutan Aesthet Surg. 2020;13(4):265-274. doi: 10.4103/JCAS.JCAS_45_20
- Finnerup NB, Attal N, Haroutounian S, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015;14(2):162- 173. doi: 10.1016/S1474-4422(14)70251-0
