AccScience Publishing / EJMO / Online First / DOI: 10.36922/EJMO025080035
Submit to EJMO
Cite this article
4
Download
57
Views
Journal Browser
Volume | Year
Issue
Search
Forthcoming Issue
Current Issue
View All
News and Announcements
View All
LETTER TO EDITOR

Is there a fresh hope for Alzheimer’s using butyrate?

Xueyi Yin1 ,  Mengjiao Zhang2 ,  Linlin Shao1*
Show Less
1 Tianjin Key Laboratory of Modern Chinese Medicine Theory of Innovation and Application, College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
2 First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China
EJMO, 025080035 https://doi.org/10.36922/EJMO025080035
Submitted: 20 February 2025 | Accepted: 11 March 2025 | Published: 27 March 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Download PDF
Cite
XML
Conflict of interest
The authors declare that they have no competing interests.
References
  1. GBD 2021 Nervous System Disorders Collaborators. Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: A systematic analysis for the global burden of disease study 2021. Lancet Neurol. 2024;23(4):344-381. doi: 10.1016/S1474-4422(24)00038-3

 

  1. Pendin D, Fasolato C, Basso E, et al. Familial Alzheimer’s disease presenilin-2 mutants affect Ca2+ homeostasis and brain network excitability. Aging Clin Exp Res 2021;33(6):1705-1708. doi: 10.1007/s40520-019-01341-0

 

  1. Sebastián-Serrano Á, De Diego-García L, Díaz- Hernández M. The neurotoxic role of extracellular tau protein. Int J Mol Sci. 2018;19(4):998. doi: 10.3390/ijms19040998

 

  1. Twarowski B, Herbet M. Inflammatory processes in Alzheimer’s disease-pathomechanism, diagnosis and treatment: A review. Int J Mol Sci. 2023;24(7):6518. doi: 10.3390/ijms24076518

 

  1. Spina E, Ferrari RR, Pellegrini E, et al. Mitochondrial alterations, oxidative stress, and therapeutic implications in Alzheimer’s disease: A narrative review. Cells. 2025;14(3):229. doi: 10.3390/cells14030229

 

  1. McOrist AL, Miller RB, Bird AR, et al. Fecal butyrate levels vary widely among individuals but are usually increased by a diet high in resistant starch. J Nutr. 2011;141(5):883-889. doi: 10.3945/jn.110.128504.

 

  1. Du Y, He C, An Y, et al. The role of short chain fatty acids in inflammation and body health. Int J Mol Sci. 2024;25(13):7379. doi: 10.3390/ijms25137379.

 

  1. Barcutean L, Maier S, Burai-Patrascu M, et al. The immunomodulatory potential of short-chain fatty acids in multiple sclerosis. Int J Mol Sci. 2024;25(6):3198. doi: 10.3390/ijms25063198

 

  1. Bui TP, Ritari J, Boeren S et al. Production of butyrate from lysine and the Amadori product fructoselysine by a human gut commensal. Nat Commun. 2015;6:10062. doi: 10.1038/ncomms10062

 

  1. Facchin S, Bertin L, Bonazzi E, et al. Short-chain fatty acids and human health: From metabolic pathways to current therapeutic implications. Life (Basel). 2024;14(5):559. doi: 10.3390/life14050559

 

  1. Yamashiro K, Takabayashi K, Kamagata K, et al. Free water in gray matter linked to gut microbiota changes with decreased butyrate producers in Alzheimer’s disease and mild cognitive impairment. Neurobiol Dis. 2024;193:106464. doi: 10.1016/j.nbd.2024.106464

 

  1. Zhu G, Zhao J, Wang G, et al. Bifidobacterium breve HNXY26M4 attenuates cognitive deficits and neuroinflammation by regulating the gut-brain axis in APP/ PS1 mice. J Agric Food Chem. 2023;71(11):4646-4655. doi: 10.1021/acs.jafc.3c00652

 

  1. Sun J, Xu J, Yang B et al. Effect of clostridium butyricum against microglia-mediated neuroinflammation in Alzheimer’s disease via regulating gut microbiota and metabolites butyrate. Mol Nutr Food Res. 2020;64(2):e1900636. doi: 10.1002/mnfr.201900636

 

  1. Kim SY, Chae CW, Lee HJ et al. Sodium butyrate inhibits high cholesterol-induced neuronal amyloidogenesis by modulating NRF2 stabilization-mediated ROS levels: Involvement of NOX2 and SOD1. Cell Death Dis. 2020;11(6):469. doi: 10.1038/s41419-020-2663-1

 

  1. Ge X, Zheng M, Hu M, et al. Butyrate ameliorates quinolinic acid-induced cognitive decline in obesity models. J Clin Invest. 2023;133(4):e154612. doi: 10.1172/JCI154612

 

  1. Wang C, Zheng D, Weng F, et al. Sodium butyrate ameliorates the cognitive impairment of Alzheimer’s disease by regulating the metabolism of astrocytes. Psychopharmacology (Berl). 2022;239(1):215-227. doi: 10.1007/s00213-021-06025-0

 

  1. Jiang Y, Li K, Li X, et al. Sodium butyrate ameliorates the impairment of synaptic plasticity by inhibiting the neuroinflammation in 5XFAD mice. Chem Biol Interact. 2021;341:109452. doi: 10.1016/j.cbi.2021.109452

 

  1. Yuan B, Liu M, Gong Y, et al. Sodium butyrate exerts antioxidant stress effects and attenuates Aβ25-35-induced cytotoxicity in PC12 cells. Arch Biochem Biophys. 2022;731:109448. doi: 10.1016/j.abb.2022.109448

 

  1. Sun J, Yuan B, Wu Y, et al. Sodium butyrate protects N2a cells against Aβ toxicity in vitro. Mediators Inflamm. 2020;2020:7605160. doi: 10.1155/2020/7605160

 

Share
Back to top
Eurasian Journal of Medicine and Oncology, Electronic ISSN: 2587-196X Print ISSN: 2587-2400, Published by AccScience Publishing
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here
Accept