AccScience Publishing / EJMO / Volume 8 / Issue 3 / DOI: 10.14744/ejmo.2024.13316
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META-ANALYSIS

Is Shift Work Associated with Pancreatic Cancer? A Systematic Review and Meta-Analysis

Ahmed Arafa1,2 ,  Mohamed Elsheikh3,4
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1 Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan
2 Department of Public Health and Community Medicine, Beni-Suef University Faculty of Medicine, Beni-Suef, Egypt
3 Department of Health Informatics, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan
4 Department of Emergency Medicine and Traumatology, Tanta University Faculty of Medicine, Tanta, Egypt
EJMO 2024, 8(3), 295–301; https://doi.org/10.14744/ejmo.2024.13316
Submitted: 5 March 2024 | Accepted: 30 April 2024 | Published: 10 September 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
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Abstract

Objectives: Pancreatic cancer (PaC) is a highly fatal disease that can be influenced by occupational factors. Shift work has been suggested to be carcinogenic, yet little is known about its association with PaC. Herein, we performed this systematic review and meta-analysis to investigate the potential association between shift work and PaC.

Methods: We systematically searched PubMed and Scopus databases for eligible studies. The pooled hazard ratio (HR) and 95% confidence interval (CI) of PaC risk were calculated for those who had engaged in shift work. We used the I² statistic to measure heterogeneity across studies and the test for funnel plot asymmetry to assess publication bias.

Results: This meta-analysis incorporated five studies involving participants from various regions, including Japan, the United States, Denmark, Sweden, and Germany. Combined, shift work was not associated with PaC: HR (95% CI) =1.05 (0.91, 1.20). Neither heterogeneity across studies (I²=0.0% and p-heterogeneity = 0.913) nor publication bias (z=-0.276 and p-publication bias=0.783) was detected. The results remained consistent in both sexes and PaC incidence and mortality.

Conclusion: Shift work does not seem to elevate the risk of PaC. 

Keywords
Meta-analysis
pancreatic cancer
shift work
systematic review.
Conflict of interest
None declared.
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Eurasian Journal of Medicine and Oncology, Electronic ISSN: 2587-196X Print ISSN: 2587-2400, Published by AccScience Publishing
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