Immunohistochemical Evaluation of CD10 Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: A Cross-sectional Study
Objectives: The objective of the study is to evaluate the expression of CD10 in oral epithelial dysplasia and oral squamous cell carcinoma (OSCC) and to determine its role as a potential biomarker in OSCC.
Methods: Immunohistochemical evaluation of 40 archival paraffin-embedded tissue specimens grouped into oral epithelial dysplasia and early invasive, well-differentiated, and moderately differentiated OSCC was conducted to determine and compare the CD10 expression among the groups. Stromal positivity of the CD10 expression was calculated and statistically analyzed at p<0.05.
Results: The results of the study showed that there was a statistically significant increase in the mean CD10 expression among the four groups. Intergroup comparison showed a statistically significant difference between oral epithelial dysplasia and OSCC while statistical significance was not observed in the various grades of OSCC.
Conclusion: CD10 expression could be used as an important biomarker for determining the progression of oral epithelial dysplasia and the overall prognosis of OSCC.
1. Rao SV, Mejia G, Roberts-Thomson K, Logan R. Epidemiology of oral cancer in Asia in the past decade-an update (2000- 2012). Asian Pacific J Cancer Prev 2013;14:5567–77. [CrossRef]
2. Feller L, Lemmer J. Oral squamous cell carcinoma: epidemiology, clinical presentation and treatment. Journal of cancer therapy 2012;3:263. [CrossRef]
3. Sridharan G. Epidemiology, prevention and control of tobacco induced oral mucosal lesions in India. Ind J Cancer 2014;51:80–5. [CrossRef]
4. Warnakulasuriya S. Living with oral cancer: Epidemiology with particular reference to prevalence and life-style changes that influence survival. Oral Oncol 2010;46:407–10. [CrossRef]
5. Lumerman H, Freedman P, Kerpel S. Oral epithelial dysplasia and the development of invasive squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;79:321–9. [CrossRef]
6. Peltanova B, Raudenska M, Masarik M. Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review. Mol Cancer 2019;18:63. [CrossRef]
7. Ohshima K, Kawasaki C, Muta H, Muta K, Deyev V, Haraoka S, et al. CD10 and Bcl10 expression in diffuse large B-cell lymphoma: CD10 is a marker of improved prognosis. Histopathology 2001;39:156–62. [CrossRef]
8. Iwaya K, Ogawa H, Izumi M, Kuroda M, Mukai K. Stromal expression of CD10 in invasive breast carcinoma: a new predictor of clinical outcome. Virchows Arch 2002;440:589–93
9. Bilalovic N, Sandstad B, Golouh R, Nesland JM, Selak I, Torlakovic EE. CD10 protein expression in tumor and stromal cells of malignant melanoma is associated with tumor progression. Modern Pathology 2004;17:1251–8
10. Mishra D, Singh S, Narayan G. Role of B cell development marker CD10 in cancer progression and prognosis. Mol Biol Int 2016;2016:4328697. [CrossRef]
11. Fukusumi T, Ishii H, Koseki J, Hanamoto A, Nakahara S, Yamamoto Y, et al. Novel markers of cancer stem cells in head and neck squamous cell carcinoma. Cancer cell and microenvironment 2015;2:e701.
12. Piattelli A, Fioroni M, Iezzi G, Perrotti V, Stellini E, Piattelli M, et al. CD10 expression in stromal cells of oral cavity squamous cell carcinoma: a clinic and pathologic correlation. Oral Dis 2006;12:301–4. [CrossRef]
13. Helmy IM, Baghdady HM, Omar S. Immunohistochemical Expression of Cd10 in Oral Squamous Cell Carcinoma. Ain Shams Dental Journal 2015;425:1–7. [CrossRef]
14. Fernandez-Flores A. Cutaneous squamous cell carcinoma of different grades: variation of the expression of CD10. Cesk Patol 2008;44:100–2.
15. Ogawa H, Kuroda M, Koyanagi Y. Expression of CD10 by stromal cells during colorectal tumor development. Human Pathology 2002;33:806–11. [CrossRef]
16. Gouda MH, El-Fattah GAA, El-Sawi RM. Value of p53, Ki-67 and CD10 in keratoacanthoma and squamous cell carcinoma. Med J Cairo Univ 2014;82:795–801.