This special issue aims to delve into the critical roles that stromal cells play within the tumor microenvironment. Stromal cells, including fibroblasts, and endothelial cells, are integral components of the tumor stroma, influencing tumor growth, progression, and response to therapy. These cells interact dynamically with cancer cells, contributing to the complexity of tumor biology.

Recent research has highlighted the multifaceted functions of stromal cells, such as modulating immune responses, enhancing angiogenesis, and remodeling the extracellular matrix. Understanding these interactions is crucial for developing new therapeutic strategies aimed at targeting the tumor microenvironment.

This special issue invites Original Research Articles and Reviews that explore the mechanisms by which stromal cells affect tumor behavior, the signaling pathways involved, and potential therapeutic approaches targeting stromal components. We welcome contributions that utilize advanced techniques, AI tools and models to provide insights into the cellular and molecular dynamics of stromal cells within tumors.

By bringing together cutting-edge research, this special issue seeks to advance our understanding of stromal cell functions in cancer and foster the development of innovative treatments that can improve patient outcomes.