AccScience Publishing / CP / Online First / DOI: 10.36922/CP025480086
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ORIGINAL RESEARCH ARTICLE

Distribution and frequency of parotid gland tumors in the Anhui province: A retrospective multicenter study of 758 cases

Wenjie Zhang1 ,  Meng Luo2 ,  Xinghong Yin1,2*
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1 Department of Otorhinolaryngology Head & Neck Surgery, The Affiliated Fuyang People’s Hospital of Bengbu Medical University, Fuyang, Anhui, China
2 Department of Otorhinolaryngology Head & Neck Surgery, The Affiliated Fuyang People’s Hospital of Anhui Medical University, Fuyang, Anhui, China
CP, 025480086 https://doi.org/10.36922/CP025480086
Received: 30 November 2025 | Revised: 7 February 2026 | Accepted: 13 February 2026 | Published online: 24 April 2026
© 2026 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Parotid gland tumors are rare, exhibit complex histopathology, and often lack early clinical symptoms. Epidemiological and pathological features of parotid gland tumors in Anhui province, China, have not yet been reported. This study aimed to retrospectively analyze the distribution and histopathological characteristics of parotid gland tumors in Anhui province. We retrospectively analyzed the clinical data from 758 patients with parotid gland tumors admitted to three centers from January 2018 to January 2022. All diagnoses were unequivocally confirmed by histopathological examination. Pleomorphic adenoma and mucoepidermoid carcinoma were the most prevalent tumors. Benign and malignant tumors were detected in six hundred forty-one and one hundred seventeen patients, respectively, with a benign-to-malignant ratio of 5.48:1. A slight female predilection (51.8%) was observed. The highest incidence occurred in the 51–60 years age group. Warthin tumor was the second most prevalent benign tumor, showing a significant male predilection. The distribution and frequency of most parotid gland neoplasms in Anhui province were similar to global reports, confirming the well-known male predilection for Warthin tumor. This multicenter study provides an epidemiological baseline for better characterizing these tumors in this region.

Keywords
Parotid gland tumors
Multicenter study
Epidemiology
Histopathology
China
Funding
This study is supported by Fuyang Municipal Science and Technology Bureau 2024 Annual Project (grant no.: FYHR2024-016).
Conflict of interest
The authors declare no conflict of interest.
References
  1. Ferreira JCB, Morais MO, Elias MRA, Batista AC, Leles CR, Mendonça EF. Pleomorphic adenoma of oral minor salivary glands: An investigation of its neoplastic potential based on apoptosis, mucosecretory activity and cellular proliferation. Arch Oral Biol. 2014;59(6):578-585. doi: 10.1016/j.archoralbio.2014.03.002

 

  1. Takebayashi S, Shinohara S, Tamaki H, et al. Adenoid cystic carcinoma of the head and neck: a retrospective multicenter study. Acta Oto-Laryngologica. 2017;138(1):73-79. doi: 10.1080/00016489.2017.1371329

 

  1. Honda K, Tanaka S, Shinohara S, et al. Survival in patients with parotid gland carcinoma – Results of a multi-center study. Am J Otolaryngol. 2018;39(1):65-70. doi: 10.1016/j.amjoto.2017.10.012

 

  1. Pinkston JA, Cole P. Incidence Rates of Salivary Gland Tumors: Results from a Population‐Based Study. Otolaryngol –Head Neck Surg. 1999;120(6):834-840. doi: 10.1016/s0194-5998(99)70323-2

 

  1. Hay AJ, Migliacci J, Karassawa Zanoni D, McGill M, Patel S, Ganly I. Minor salivary gland tumors of the head and neck—Memorial Sloan Kettering experience: Incidence and outcomes by site and histological type. Cancer. 2019;125(19):3354-3366. doi: 10.1002/cncr.32208

 

  1. Alramadhan SA, Fitzpatrick SG, Cohen DM, Bhattacharyya I, Islam MN. Retrospective Study of Buccal Mucosal Salivary Neoplasms. Head Neck Pathol. 2020;14(4):1013-1020. doi: 10.1007/s12105-020-01190-8

 

  1. Sentani K, Ogawa I, Ozasa K, Sadakane A, Utada M, Tsuya T, et al. Characteristics of 5015 Salivary Gland Neoplasms Registered in the Hiroshima Tumor Tissue Registry over a Period of 39 Years. JCM. 2019;8(5):566. doi: 10.3390/jcm8050566

 

  1. Aldelaimi AA, Enezei HH, Aldelaimi TN, Mohammed KA, Al-Ani RM. Salivary Gland Diseases: A Retrospective Clinicopathological Study of 159 Cases. Cureus. 2022;14(9). doi: 10.7759/cureus.29589

 

  1. Grosheva M, Shabli S, Volk GF et al. Sensation loss after superficial parotidectomy: A prospective controlled multicenter trial. Head Neck. 2017;39(3):520-526. doi: 10.1002/hed.24647

 

  1. El-Naggar AK, Chan JKC, Takata T, Grandis JR, Slootweg PJ. The fourth edition of the head and neck World Health Organization blue book: editors’ perspectives. Hum Pathol. 2017;66:10-12. doi: 10.1016/j.humpath.2017.05.014

 

  1. Jansen L, Mayer M, Stang A et al. Incidence and survival of primary major salivary gland carcinoma in Germany over the last decade: A nationwide population-based study. Eur J Cancer. 2026;234:116196. doi: 10.1016/j.ejca.2025.116196

 

  1. Bassani S, Santonicco N, Eccher A et al. Artificial intelligence in head and neck cancer diagnosis. J Pathol Inform. 2022;13:100153. doi: 10.1016/j.jpi.2022.100153

 

  1. Alsanie I, Rajab S, Cottom H et al. Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study. Head Neck Pathol. 2022;16(4):1043-1054. doi: 10.1007/s12105-022-01459-0

 

  1. Da Silva LP, Serpa MS, Viveiros SK et al. Salivary gland tumors in a Brazilian population: A 20-year retrospective and multicentric study of 2292 cases. J Craniomaxillofac Surg. 2018;46(12):2227-2233. doi: 10.1016/j.jcms.2018.09.028

 

  1. Fonseca FP, Carvalho MDV, de Almeida OP et al. Clinicopathologic analysis of 493 cases of salivary gland tumors in a Southern Brazilian population. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114(2):230-239. doi: 10.1016/j.oooo.2012.04.008

 

  1. Kızıl Y, Aydil U, Ekinci O et al. Salivary gland tumors in Turkey: demographic features and histopathological distribution of 510 patients. Indian J Otolaryngol Head Neck Surg. 2013;65(S1):112-120. doi: 10.1007/s12070-012-0594-6

 

  1. Tian Z, Li L, Wang L, Hu Y, Li J. Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg. 2010;39(3):235-242. doi: 10.1016/j.ijom.2009.10.016

 

  1. Ito FA, Ito K, Vargas PA, de Almeida OP, Lopes MA. Salivary gland tumors in a Brazilian population: a retrospective study of 496 cases. Int J Oral Maxillofac Surg. 2005;34(5):533-536. doi: 10.1016/j.ijom.2005.02.005

 

  1. Bradley PJ, McGurk M. Incidence of salivary gland neoplasms in a defined UK population. Br J Oral Maxillofac Surg. 2013;51(5):399-403. doi: 10.1016/j.bjoms.2012.10.002

 

  1. Vasconcelos AC, Nör F, Meurer L, et al. Clinicopathological analysis of salivary gland tumors over a 15-year period. Braz oral res. 2016;30(1). doi: 10.1590/1807-3107bor-2016.vol30.0002

 

  1. Lopes MLDD, Barroso KMA, Henriques ÁCG et al. Pleomorphic adenomas of the salivary glands: retrospective multicentric study of 130 cases with emphasis on histopathological features. Eur Arch Otorhinolaryngol. 2017;274(1):543-551. doi: 10.1007/s00405-016-4253-5

 

  1. Matsumiya-Matsumoto Y, Morita Y, Uzawa N. Pleomorphic Adenoma of the Salivary Glands and Epithelial- Mesenchymal Transition. J Clin Med. 2022;11(14). doi: 10.3390/jcm11144210

 

  1. Zbären P, Stauffer E. Pleomorphic adenoma of the parotid gland: histopathologic analysis of the capsular characteristics of 218 tumors. Head Neck. 2007;29(8):751-757. doi: 10.1002/hed.20569

 

  1. Witt RL, Eisele DW, Morton RP et al. Etiology and management of recurrent parotid pleomorphic adenoma. Laryngoscope. 2015;125(4):888-893. doi: 10.1002/lary.24964

 

  1. Franzen AM, Kaup Franzen C, Guenzel T, Lieder A. Increased incidence of Warthin tumours of the parotid gland: a 42-year evaluation. Eur Arch Otorhinolaryngol. 2018;275(10):2593-2598. doi: 10.1007/s00405-018-5092-3

 

  1. Saravakos P, Kourtidis S, Hartwein J, Preyer S. Parotid Gland Tumors: A Multicenter Analysis of 1020 Cases. Increasing Incidence of Warthin’s Tumor. Indian J Otolaryngol Head Neck Surg. 2022;74(Suppl 2):2033-2040. doi: 10.1007/s12070-020-01981-z

 

  1. Gao M, Hao Y, Huang MX et al. Salivary gland tumours in a northern Chinese population: a 50-year retrospective study of 7190 cases. Int J Oral Maxillofac Surg. 2017;46(3):343-349. doi: 10.1016/j.ijom.2016.09.021

 

  1. Taghavi N, Sargolzaei S, Mashhadiabbas F, Akbarzadeh A, Kardouni P. Salivary Gland Tumors: A 15- year Report from Iran. Turk Patoloji Derg. 2016;32(1):35-39. doi: 10.5146/tjpath.2015.01336

 

  1. Lee YM, Choi HJ, Kim JW, Kim JH. Parotid gland tumors in a Korean population. J Craniofac Surg. 2012;23(3):e205-e209. doi: 10.1097/SCS.0b013e31824de357
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