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CASE REPORT
Plummer–Vinson syndrome complicated by Schatzki ring, non-Hodgkin lymphoma, and myeloproliferative disorder: A rare case report from Pakistan
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1 Patients Diagnostic Lab, Faculty of Technology, Pakistan Institute of Nuclear Science and Technology, Islamabad,
Pakistan
2 Department of Biological Sciences, Faculty of Biotechnology, International Islamic University, Islamabad,
Pakistan
3 Department of Medical Laboratory Technology, Institute of Allied Health Sciences, Wah Medical College, National University of Medical Sciences, Rawalpindi, Punjab,
Pakistan
4 Department of Gastroenterology, Center of Liver and Digestive Diseases, Holy Family Hospital, Rawalpindi, Punjab,
Pakistan
5 Department of Biochemistry, Faculty of Basic Medical Sciences, Wah Medical College, National University of Medical Sciences, Rawalpindi,
Pakistan
Received: 11 July 2025 | Revised: 18 September 2025 | Accepted: 21 October 2025 | Published online: 31 December 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
We report a rare case of Plummer–Vinson syndrome (PVS) in a 55-year-old female with no known premorbid condition who presented to the hospital with a chief complaint of dysphagia for 1 month, weight loss, and a history of fever (high grade up to 40°C) associated with occasional rigors and chills. Laboratory testing showed iron-deficiency anemia, together with dysphagia, raising clinical suspicion for PVS. She was further examined with upper gastrointestinal endoscopy to evaluate the cause of dysphagia, which revealed a Schatzki ring in the esophagus at 38 cm from the incisors, near the gastroesophageal junction. The ring was dilated endoscopically, and the rest of the stomach and duodenum were normal. The computed tomography scan presented hepatosplenomegaly and lymphadenopathy. Findings were consistent with a myeloproliferative disorder and non-Hodgkin lymphoma. Oral iron supplementation (150–200 mg) was recommended, and dysphagia should be evaluated with gastroduodenal endoscopy as indicated.
Keywords
Plummer–Vinson syndrome
Esophageal webs
Iron deficiency
Postcricoid dysphagia
Funding
This case study was part of a PhD research study financially supported by the Pakistan Science Foundation (Project # PSF/Res/C-PINSTECH/Med531).
Conflict of interest
The authors declare that they have no competing interests.
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