CASE REPORT

Primary hypothyroidism in a patient with germ cell tumor: A case report

Parmod Kumar1 Varsha Dholiya2 Shraddha Tiwari2 Amit Sehrawat2*
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1 Department of Medical Oncology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
2 Department of Medical Oncology Hematology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
CP 2024, 6(2), 3376
Submitted: 7 April 2024 | Accepted: 31 May 2024 | Published: 19 June 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Germ cell tumors (GCTs) are known to present with thyroid dysfunction, typically manifesting as hyperthyroidism due to human chorionic gonadotropin secretion. However, hypothyroidism among GCT patients is a relatively underexplored phenomenon, which could be attributable to low clinical suspicion and the potential masking of hypothyroidism by cancer-related symptoms. Moreover, the impact of hypothyroidism on cancer-related outcomes remains uncertain. Here, we present a case of incidentally detected primary hypothyroidism in a 16-year-old girl with an ovarian GCT. Remarkably, her condition improved at an unexpected rate after cancer-directed treatment. In our evaluation, we identified various causes of reversible hypothyroidism, all of which are comprehensively reviewed in this case report.

Keywords
Germ cell tumors
Primary hypothyroidism
Transient hypothyroidism
Rifampicin-induced thyroid dysfunction
Funding
None.
Conflict of interest
The authors declare no conflicts of interest.
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