Primary hypothyroidism in a patient with germ cell tumor: A case report

Parmod Kumar1 Varsha Dholiya2 Shraddha Tiwari2 Amit Sehrawat2*
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1 Department of Medical Oncology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
2 Department of Medical Oncology Hematology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
CP 2024, 6(2), 3376
Submitted: 7 April 2024 | Accepted: 31 May 2024 | Published: 19 June 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( )

Germ cell tumors (GCTs) are known to present with thyroid dysfunction, typically manifesting as hyperthyroidism due to human chorionic gonadotropin secretion. However, hypothyroidism among GCT patients is a relatively underexplored phenomenon, which could be attributable to low clinical suspicion and the potential masking of hypothyroidism by cancer-related symptoms. Moreover, the impact of hypothyroidism on cancer-related outcomes remains uncertain. Here, we present a case of incidentally detected primary hypothyroidism in a 16-year-old girl with an ovarian GCT. Remarkably, her condition improved at an unexpected rate after cancer-directed treatment. In our evaluation, we identified various causes of reversible hypothyroidism, all of which are comprehensively reviewed in this case report.

Germ cell tumors
Primary hypothyroidism
Transient hypothyroidism
Rifampicin-induced thyroid dysfunction
  1. Carter Y, Sippel RS, Chen H. Hypothyroidism after a cancer diagnosis: Etiology, diagnosis, complications, and management. Oncologist. 2014;19(1):34-43. doi: 10.1634/theoncologist.2013-0237


  1. Kansara M, Yadav G, Gothwal M, Singh P. Yolk sac tumour of ovary with fever and overt hypothyroidism: Rare clinical presentation. BMJ Case Rep. 2020;13(1):e232114. doi: 10.1136/bcr-2019-232114


  1. Brent GA, Weetman AP. Hypothyroidism and thyroiditis. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, editors. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020. p. 404-432.


  1. Lee SY, Rhee CM, Leung AM, Braverman LE, Brent GA, Pearce EN. A review: Radiographic iodinated contrast media-induced thyroid dysfunction. J Clin Endocrinol Metab. 2015;100(2):376-383. doi: 10.1210/jc.2014-3292


  1. Rothacker KM, Walsh JP. Acute and subacute thyroiditis. In: Vitti P, Hegedus L, editors. Thyroid Diseases. Endocrinology. Cham: Springer; 2016. doi: 10.1007/978-3-319-29195-6_9-1


  1. Kim HI, Kim TH, Kim H, et al. Effect of Rifampin on thyroid function test in patients on levothyroxine medication. PLoS One. 2017;12(1):e0169775. doi: 10.1371/journal.pone.0169775


  1. Takasu N, Kinjou Y, Kouki T, Takara M, Ohshiro Y, Komiya I. Rifampin-induced hypothyroidism. J Endocrinol Invest. 2006;29(7):645-649. doi: 10.1007/BF03344165


  1. Weber Pasa M, Scheffel RS, Borsatto Zanella A, Maia AL, Dora JM. Consumptive hypothyroidism: Case report of hepatic hemangioendotheliomas successfully treated with vincristine and systematic review of the syndrome. Eur Thyroid J. 2017;6(6):321-327. doi: 10.1159/000481253
Conflict of interest
The authors declare no conflicts of interest.
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