Preoperative Radiotherapy and Chemotherapy for Rectal Cancer
The objective of this study is to investigate the complete pathological reaction of preoperative radiotherapy and chemotherapy for rectal cancer. We conducted a retrospective and explanatory study to evaluate the reaction to preoperative radiotherapy and chemotherapy in 46 patients of stage I, II and III rectal adenocarcinoma from 2006 to 2014. These patients were divided into four groups, in which 52.17% complete remission (24 cases), 15.21% moderate remission (7 cases), 6.53% minimum remission (3 cases) and 26.09% adverse reactions (12 cases). In this study, more than 50% of patients with preoperative radiotherapy and chemotherapy show complete pathological response, which may provide the possibility for patients with rectal adenocarcinoma to receive this treatment in the future, and a carefully selected group among the patients will enter the observation period.
Ministry of Public Health. Cancer Mortality in Venezuela in 2011 [Mortalidad por cáncer en Venezuela año 2011]. Available from: website: http//.www.mpps.gob.ve.
Halperin EC, Perez CA, Brady LW, 2008, Perez & Brady’s Principles and Practice of Radiation Oncology (5th edn). Philadelphia: Williams and Wilkin, pp.1372–9.
Singh-Ranger G, Kumar D, 2011, Current Concepts in the Non-operative Management of Rectal Cancer After Neoadjuvant Chemo-radiation. Anticancer Res, 31:1795–17800.
Mak RH, McCarthy EP, Das P, et al, 2011, Adoption of Preoperative Radiation Therapy for Rectal Cancer from 2000 to 2006: A Surveillance, Epidemiology, and End Results Patterns of Care Study. Int J Radiat Oncol Biol Phys, 80:978–984. DOI: 10.1016/j.ijrobp.2010.03.056.
Ceelen WP, Van Nieuwenhove Y, Fierens K, 2009, Preoperative Chemo-radiation VS. Radiation Alone for Stage II and III Resecable Rectal Cancer. Cochrane Database Syst Rev, cd006041.
Sauer R1, Liersch T, Merkel S, et al., 2012, Preoperative Versus Postoperative Chemo-radiotherapy for Locally Advanced Rectal Cancer: Results of the German CAO/ARO/AIO-94 Randomized Phase III Trial After a Median Follow-up of 11 years. J Clin Oncol, 30:1926–33. DOI: 10.1200/JCO.2011.40.1836.
Ryan R, Gibbons D, Hyland JMP, et al., 2005, Pathological Response Following Long-course Neoadyuvante Chemo-radiotherapy for Locally Advanced Rectal Cancer. Histopathology, 47:141–6. DOI: 10.1111/j.1365-2559.2005.02176.x.
Garajová I, Di Girolamo S, de Rosa F, et al., 2011, Neoadjuvant Treatment in Rectal Cancer: Actual Status. Chemother Res Pract, 839742. DOI: 10.1155/2011/839742.
Benzoni E, Cerato F, Cojutti A, et al., 2005, The Predictive Value of Clinical Evaluation of Response to Neoadjuvant Chemo-radiation Therapy for Rectal Cancer. Tumori, 91:401–5.
Habr-Gama A, Perez R, Proscurshim I, et al., 2010, Complete Clinical Response After Neoadjuvant Chemo-radiation for Distal Rectal Cancer. Surg Oncol Clin N Am, 19:829–45. DOI: 10.1016/j.soc.2010.08.001.
Habr-Gama A, Perez RO, Nadalin W, et al., 2005, Long-term Results of Preoperative Chemo-radiation for Distal Rectal Cancer Correlation Between Final Stage and Survival. J Gastrointest Surg, 9:90–9. DOI: 10.1016/j.gassur.2004.10.010.
Habr-Gama A, Gama-Rodrigues J, São Julião GP, et al., 2014, Local Recurrence After Complete Clinical Response and Watch and Wait in Rectal Cancer After Neoadjuvant Chemoradiation: Impact of Salvage Therapy on Local Disease Control. Int J Radiat Oncol Biol Phys, 88:822–8.
Damin DC, Lazzaron AR, 2014, Evolving Treatment Strategies for Colorectal Cancer: A Critical Review of Current Therapeutic Options. World J Gastroenterol, 20:877–7. DOI: 10.3748/wjg.v20.i4.877.
Wang T, Wang J, Deng Y, et al., 2014, Neoadjuvant Therapy Followed by Local Excision and Two-stage Total Mesorectal Excision: A New Strategy for Sphincter Preservation in Locally Advanced Ultra-Low Rectal Cancer. Gastroenterol Rep (Oxf), 2:37–43. DOI: 10.1093/gastro/got040.