Risk and Protective Factors Associated with Breast Cancer
Objective: To determine the risk factors according to age group, gynecological history, personal and family background, and the potential breast cancer protective factors of breast cancer patients who visited the gynecological clinic of the University Hospital of Caracas from January 2013 to December 2015 were determined. Method: Retrospective, descriptive, observational and cross-sectional studies. Result: 110 patients were female; the average age was 53 years and 3 months. The age of menarche is 12 years and 5 months. 77% were menopausal, with an average age of 48 years and 1 month, and only 5% received hormone replacement therapy. 92% were multiple pregnancies, and the first delivery age was 21 years and 5 months. Only 8% were ineffective and 33% had a history of abortion. 24% had a family history of primary or secondary breast cancer. 40% of women use hormonal contraceptives for an average of 21 months, and 72% of women breastfeed. Conclusion: Age, gender, personal and family background are consistent with international publications. In contrast, the use of oral contraceptives is not considered a risk factor, and breastfeeding is not considered a protective factor.
International Agency for research on cancer (IARC), 2014, Informe mundial sobre el cáncer 2014 [World Cancer Report 2014]. Available from: http://www.iarc.fr/.
Office for National Statistics, Cancer Registration Statistics. Available from: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html.
ISD Scotland. Available from: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp#605.
Breast Cancer Information and Awareness. Available from: http://www.breastcancer.org/.
Estimated Cancer Incidence Mortality and Prevalence Worldwide. GLOBOCAN 2012 (IARC). Available from: http://globocan.iarc.fr/.
MPPS-Ministerio del Poder Popular para la Salud, 2012, Anuario de Mortalidad 2012 [Mortality Yearbook 2012]. Caracas: Venezuela. Available from: http://www.mpps.gob.ve.
Martin A, Weber B, 2000, Genetic and Hormonal Risk Factors in Breast Cancer. J Natl Cancer Inst, 92:1126–35.
Vogel VG, 2003, Management of the High Risk Patient. Surg Clin North Am, 83:733–51.
Bars J, Hull J, Levy-Lahad E, et al., Breast Cancer Genetics—An Overview. Available from: http://web.udl.es/usuaris/e4650869/docencia/segoncicle/genclin98/malalties/Breast%20Cancer%20.pdf.
Singletary E, 2003, Rating the Risk Factors for Breast Cancer. Ann Surg, 237:474–82.
Fric M, Speroff L, 2012, Endocrinología ginecológica clínica y esterilidad [Clinical Gynecologic Endocrinology and Infertility]. Lippincott Williams & Wilkins.
Bajares M, Pizzi R, 2013, Consenso anticoncepción hormonal 2013 [Consensus on Hormonal Contraception 2013]. Caracas: Ateproca, pp.77–9.
Gail M, Brinton L, Byar D, et al., 1989, Projecting Individualized Probabilities of Developing Breast Cancer for White Females Who Are Being Examined Annually. J Natl Cancer Inst, 81:1879–86.
Claus E, Risch N, Thompson W, 1994, Autosomal Dominant Inheritance of Early-Onset Breast Cancer: Implications for Risk Prediction. Cancer, 73:643–51.
Ozmen V, Ozcinar B, Karanlik H, et al., 2009, Breast Cancer Risk Factors in Turkish Women a University Hospital Based Nested Case Control Study. World J Surg Onc, 7:37.
Collaborative Group on Hormonal Factors in Breast Cancer Menarche, Menopause, and Breast Cancer Risk: Individual Participant Meta-Analysis, Including 118,964 Women with Breast Cancer from 117 Epidemiological Studies, 2012. Lancet Oncol, 13:1141–51.
Olaya-Contreras P, Pierre B, Lazcano-Ponce E, et al., 1999, Reproductive Risk Factors Associated with Breast Cancer in Columbian Women. Rev Saúde Pública, 33:237–45.
Hernández D, Borges R, Márquez G, et al., 2010, Factores de Riesgo Conocidos Para Cáncer de Mama. Pacientes Con Cáncer Patología Benigna no Patología [Known Risk Factors for Breast Cancer. Patients with Benign Cancer Pathology with No Pathology]. Rev Venez Oncol, 22:16–31.
Zahra F, Bouayad A, Hasswane N, et al., 2015, Risk Factors for Breast Cancer of Different Age Groups: Moroccan Data. Open J Obstet Gynecol, 5:79–87.
Badar F, Mahmood S, Faraz R, et al., 2015, Epidemiology of Breast Cancer at the Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan. J Coll Physicians Surg Pak, 25:738–42.
Titus-Ernstoff L, Longnecker M, Newcomb P, et al., 1998, Menstrual Factors in Relation to Breast Cancer Risk. Cancer Epidemiol Biomarkers Prev, 7:783–9.
Turati F, La Vecchia C, 2012, Risk Factors for Breast Cancer in China: Similarities and Differences with Western Populations. Arch Med Sci, 8:179–82.
Surakasula A, Chary G, Raghavaiah K, 2014, A Comparative study of Pre- and Post-Menopausal Breast Cancer: Risk Factors, Presentation, Characteristics and Management. J Res Pharm Pract, 3:12–8.
Ewertz M, Duffy S, 1988, Risk of Breast Cancer in Relation to Reproductive Factors in Denmark. Br J Cancer, 58:99–104.
Ortiz C, Galván E, 2007, Factores de Riesgo Reproductivos Para Cáncer de Mama en Pacientes Atendidas en un Hospital Urbano de Segundo Nivel [Reproductive Risk Factors for Breast Cancer in Patients Attended at a Second-Level Urban Hospital]. Ginecol Obstet Mex, 75:11–16.
Atalah E, Urteaga C, Rebolledo A, et al., 2000, Factores de Riesgo del Cáncer de Mama en Mujeres de Santiago [Risk Factors for Breast Cancer in San Diego Women]. Rev Med Chile, 128:137–43.
Nisar A, Naim M, Rehman N, et al., 2014, Breast Cancer; Frequency of Risk Factors. Professional Med J, 21:1128–32.
Kahlenborn C, Modugno F, Potter D, et al., 2006, Oral Contraceptives as Risk Factors for Perimenopausal Breast Cancer: Meta Analysis. Mayo Clinic Proc, 81:1290–302.
Tessaro S, Béria J, Tomasi E, et al., 2003, Breastfeeding and Breast Cancer: A Case-Control Study in Southern Brazil. Cad Saúde Pública, 19:1593–601.
Michels K, Trichopoulos D, Rosner B, et al., 2001, Being Breastfed in Infancy and Breast Cancer Incidence in Adult Life: Results from the Two Nurses’ Health Studies. Amr J Epidemiol, 153:275–83.