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REVIEW

Oxidative stress and neurological disorders: Therapeutic strategies and pharmacological intervention

Nikhila Khola1† ,  Kareena Moar1† ,  Pawan Kumar Maurya1*
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1 Department of Biochemistry, School of Interdisciplinary and Applied Sciences, Central University of Haryana, Mahendergarh, Haryana, India
Brain & Heart 2024, 2(2), 2704 https://doi.org/10.36922/bh.2704
Submitted: 10 January 2024 | Accepted: 20 March 2024 | Published: 14 May 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Oxidative stress plays a significant role in cerebral biochemical dysfunction, contributing to the increased sensitivity of the central nervous system to reactive oxygen species (ROS)-mediated injury. It is characterized by an imbalance between the production of ROS and the antioxidant capacity of the cell, which results in a variety of pathological disorders and diseases, including neurological conditions such as Parkinson’s disease, Alzheimer’s disease, schizophrenia, bipolar disorder, and anxiety. In this review, we delve into the role of oxidative stress in neurodegenerative disorders. We conducted a comprehensive search across various databases, including Google Scholar, ScienceDirect, and PubMed, with a focus on literature published within the past decade. Our search utilized terms such as “oxidative stress and neurological disorders,” “pharmacological interventions for neurological disorders,” “oxidative stress, free radicals, and neurological disorders,” and “free radicals and neurological disorders. Our aim was to elucidate the relationship between oxidative stress and neurological disorders, as well as to summarize available therapies and pharmacological interventions for these conditions.

Keywords
Oxidative stress
Neurological disorder
Reactive oxygen species
Pharmacological interventions
Therapy
Funding
Nihila Khola is a recipient of a fellowship from the Central University of Haryana. Kareena Moar is a recipient of a junior research fellowship from the Haryana State Council for Science, Innovation and Technology (HSCIT-3946). This agency had no role in the interpretation or writing the manuscript. The Indian Council of Medical Research (ICMR), Government of India, is gratefully acknowledged by Pawan Kumar Maurya for giving financial assistance (5/10/FR/03/2021-RBMCH).
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Conflict of interest
The authors declare no conflicts of interest.
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Brain & Heart, Electronic ISSN: 2972-4139 Published by AccScience Publishing
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