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Determining beta radiation doses from Y-90 microsphere for the treatment of hepatic tumors by using Monte Carlo and analytical methods
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1
Division of Medical Physics, Institute of Radiation Protection and Dosimetry, Rio de Janeiro,
Brazil
2
Department of Exact and Applied Social Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Rio Grande do Sul,
Brazil
Submitted: 12 May 2024 | Accepted: 26 June 2024 | Published: 13 August 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
The very short range of beta radiation is a potential radiation treatment for tumor, which can preserve sensitive structures. However, due to the limited range of beta radiation, practical dosimetry of beta sources may be a point of concern, and theoretical dosimetry methods play an important role. A resin microsphere loaded with the Yttrium-90 (Y-90) radionuclide can be applied in the radioembolization of hepatic tumors. In this work, we present initial calculations of dose rates around a microsphere loaded with the Y-90 radionuclide uniformly distributed on its exterior surface. Two approaches were used to carry out the estimations: the first one by means of Monte Carlo simulations using the PENELOPE code and the second one by means of the beta-point dose function formalism. A Fortran code was developed to handle with the various quantities necessary to perform the numerical integration of the beta-point dose function. A comparison between results obtained by means of both methods indicated a maximum difference of ~5% up to the 0.3 cm distance from the center of the sphere.
Keywords
Radioembolization
Beta particles
Yttrium-90
Monte Carlo method
Beta-point dose function
Funding
None.
Conflict of interest
The authors declare that they have no competing interests.
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