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Global research trends in bone/cartilage organoids from 2010 to 2024: A bibliometric and visualization study

Aikang Li1,2 ,  Rongji Liang1,3 ,  Weibei Sheng2 ,  Xiaohao Wu4 ,  Liang Gao5,6 ,  Weijin Guo7 ,  Peng Liu8 ,  Hui Zeng9 ,  Fuyang Cao10* ,  Yanbin Peng11* ,  Jianjing Lin3*
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1 Shantou University Medical College, Shantou University, Shantou, Guangdong, China
2 Department of Orthopedics, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
3 Department of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
4 Division of Immunology and Rheumatology, School of Medicine, Stanford University, Palo Alto, California, United States of America
5 Berlin Center of Clinical Medicine, Huatuo Insitute of Medical Innovation (HTIMI), Berlin, Germany
6 Department of Clinical Research and Development, Benovus Medical Technology (BMT) Corporation, Chengdu, China
7 Department of Biomedical Engineering, Shantou University, Shantou, Guangdong, China
8 National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
9 Department of Orthopedics, Shenzhen Second People’s Hospital (First Affiliated Hospital of Shenzhen University), Shenzhen, Guangdong, China
10 Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
11 Department of Hand & Microsurgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
OR, 8295 https://doi.org/10.36922/or.8295
Submitted: 30 September 2024 | Revised: 20 October 2024 | Accepted: 23 January 2025 | Published: 16 April 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
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Abstract

Bone/cartilage organoids have garnered significant attention in regenerative medicine due to their promising applications in tissue repair and disease modeling. Despite this growing interest, there is still a gap in understanding global research trends and developments in this field. This study provides a comprehensive review of the present status and emerging directions of bone/cartilage organoid research worldwide. Utilizing data from 288 records in the Web of Science Core Collection (2010 – 2024), we employed R, VOSviewer, CiteSpace, and GraphPad Prism to analyze the literature’s historical development, general characteristics, and keyword distributions. The analysis revealed a steady increase in publications since 2010, peaking in 2023, with the United States leading in contributions, and Bioactive Materials as the most influential journal. Noteworthy authors included Jiacan Su from China and Hans Clevers from the Netherlands. Research subareas were clustered into seven themes: Regenerative Medicine, Bone Regeneration, Bone Marrow Organoids, Differentiation, Extracellular Matrix, Expression, and Protein-Based Culture. Four main research directions were identified: stem cells and the microenvironment, biomaterials, regenerative medicine, and disease modeling/drug screening. This first bibliometric study on bone/cartilage organoids establishes a knowledge map, identifies key trends, and pinpoints potential hotspots, offering valuable insights for future research in this evolving field.

Graphical abstract
Keywords
Bibliometric
Visualization
Bone/cartilage organoids
Tissue engineering
Funding
This study was supported by the Guangdong Basic and Applied Basic Research Foundation (project numbers: 2023A1515220019, 2022A1515220056), the Sanming Project of Medicine in Shenzhen (project number: SZSM202211019), the “Merro” Young Physician Innovation and Development Project (project number: GSKQNJJ-2023-004), and the Shenzhen Science and Technology Program (project number: JCYJ20240813115833044).
Conflict of interest
The authors declare that there are no conflicts of interest regarding the publication of this paper.
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