The 12th OR Young Editorial Board Forum was successfully held online, attracting more than 11,000 views. Chaired by Dr. Han Liu, the forum featured presentations by Dr. Jun Tian (Southern University of Science and Technology) on combined targeted and immunotherapy for BRAF-mutant colorectal cancer and Dr. Kaiyue Zhang (Columbia University) on self-amplifying RNA therapy for durable cardioprotection. The event highlighted recent advances in precision oncology, RNA therapeutics, and translational biomedical research while promoting academic exchange within the global organoid research community.