Diverse forms and levels of intelligence manifest in humans, numerous animals, and certain machines. Artificial intelligence (AI) harnesses datasets and computer science to address issues, offer forecasts, and carry out categorizations. AI involves subfields like machine learning and deep learning. This special issue focuses on AI's role in medical applications, including disease screening, diagnosis, personalized medicine, medical imaging, drug clinical trials, healthcare, and drug design. We welcome research contributions that explore the application of AI in medicine.