AccScience Publishing / JCTR / Online First / DOI: 10.36922/jctr.24.00039
COMMENTARY

Reprogramming of lipid droplets by host cells as a defense mechanism against viral infection

Chunfu Zheng1*
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1 Department of Microbiology, Immunology and Infectious Diseases University of Calgary, Canada
Submitted: 8 July 2024 | Revised: 21 September 2024 | Accepted: 6 January 2025 | Published: 23 January 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

A recent study revealed the crucial roles of host cells in reprogramming lipid droplet (LD) synthesis to resist viral infection. Understanding the molecular mechanisms of host resistance to viral infection is necessary to develop safe and effective strategies to control viral infection. This study provides a thorough examination of the interplay between the transcription factor YY1 and LD synthesis in the context of viral infection, with potential implications for both fundamental research and practical applications in the swine industry.

Keywords
Viral infection
Lipid droplet
Host cell reprogramming
Antiviral mechanism
Funding
None.
Conflict of interest
None.
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Journal of Clinical and Translational Research, Electronic ISSN: 2424-810X Print ISSN: 2382-6533, Published by AccScience Publishing