AccScience Publishing / JCTR / Volume 9 / Issue 5 / DOI: 10.18053/jctres.09.202305.23-00010
REVIEW ARTICLE

Heart failure research paradigms using bedside observation on endothelial muscle common denominators to highlight important translational questions

Pupalan Iyngkaran1,2* Fahad Hanna2 Maximilian De Courten3 Sharmalar Rajendran4
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1 Melbourne Clinical School, The University of Notre Dame, Melbourne, Victoria, Australia
2 Program of Public Health, Torrens University Australia, Melbourne, Victoria, Australia
3 Mitchell Institute, Victoria University, Melbourne, Victoria, Australia
4 Northern Adelaide Local Health Network, South Australia, Australia
Submitted: 11 January 2023 | Revised: 17 July 2023 | Accepted: 16 August 2023 | Published: 30 September 2023
© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

Background & aim: Congestive heart failure (CHF) imposes a relevant burden on healthcare systems, as it is associated with high morbidity and mortality rates and considerable costs. Within the last three to four decades, there have been revolutionary advancements, particularly in the pharmaceutical industry. In addition, health services research at the population level has also delivered. A third avenue for advancing the clinical management of CHF is to explore established therapies with a new approach. In this perspective, we explore these established concepts and provide impetus for using bedside observations to find improvements in CHF outcomes.

Conclusion: There are potentially new concepts that can be brought to established solutions for CHF. Encouraging observations when delivering established guideline-directed medical therapies are issues that the evidence-based medicine community should factor alongside novel discoveries to improve CHF prognosis. An emphasis on innovating on the known can be considered as an important paradigm for discovery.

Relevance for patients: Patients with CHF receiving current available treatments have improved outcomes; however those not improving could be considered under evolving research paradigms.

Keywords
Clinical translation
Congestive heart failure
Endothelial dysfunction
Nitric oxide
Skeletal muscle
Conflict of interest
All authors have received government and non-governmental funding. The authors declare no conflicts of interest.
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Journal of Clinical and Translational Research, Electronic ISSN: 2424-810X Print ISSN: 2382-6533, Published by AccScience Publishing