AccScience Publishing / ITPS / Volume 7 / Issue 1 / DOI: 10.36922/itps.1386
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Guidelines for treating spinal cord injury without radiological abnormalities in children

Ruba Altahla1 Jamal Alshorman2 Xu Tao1*
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1 Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2 Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
INNOSC Theranostics and Pharmacological Sciences 2024, 7(1), 1386 https://doi.org/10.36922/itps.1386
Submitted: 27 July 2023 | Accepted: 6 September 2023 | Published: 13 October 2023
© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

Spinal cord injury without radiological abnormality (SCIWORA) is a rare condition that predominantly affects children. The enigmatic nature of SCIWORA poses significant challenges in terms of diagnosis, treatment, and achieving full recovery. Various factors, such as different injury mechanisms, delayed symptom onset, normal magnetic resonance imaging findings in certain cases, and complex management decisions, contribute to the challenges of dealing with SCIWORA. Attaining a significant outcome and complete recovery through a single-treatment approach is difficult. Therefore, a multifaceted treatment strategy is proposed to yield more favorable results. This paper comprehensively addresses the assessment and management, examination and diagnosis procedures, treatment methods, rehabilitation techniques, and potential complications associated with SCIWORA in children. The paper provides therapeutic guidance for physicians and medical staff, with the aim of enhancing survival rates and improving recovery outcomes. Moreover, it offers suggestions for restoring neurological functions in pediatric patients suffering from SCIWORA.

Keywords
Spinal cord injury without radiological abnormality
Pediatrics
Magnetic resonance imaging
Surgery
Therapeutic treatment
Rehabilitation
Funding
National Natural Science Foundation of China
References
  1. Pang D, 2004, Spinal cord injury without radiographic abnormality in children, 2 decades later. Neurosurgery, 55: 1325–1342; discussion 1342–1343. https://doi.org/10.1227/01.neu.0000143030.85589.e6

 

  1. Tong AN, Zhang JW, Zhou HJ, et al., 2020, Ischemic damage may play an important role in spinal cord injury during dancing. Spinal Cord, 58: 1310–1316. https://doi.org/10.1038/s41393-020-0503-x

 

  1. Scatchard R, Rosa JA, Bowen P, et al., 2018, A case report: Paediatric surfer’s myelopathy. Eur J Paediatr Neurol, 22: 199–202. https://doi.org/10.1016/j.ejpn.2017.09.011

 

  1. Ayaz SB, Gill ZA, Khan AA, et al., 2014, Spinal cord injury without radiographic abnormalities (SCIWORA) in a preschool child: A case report. J Postgrad Med Inst, 28: 228–230.

 

  1. Liang QC, Yang B, Song YH, et al., 2019, Real spinal cord injury without radiologic abnormality in pediatric patient with tight filum terminale following minor trauma: A case report. BMC Pediatr, 19: 513. https://doi.org/10.1186/s12887-019-1894-8

 

  1. Alshorman JA, Wang Y, Zhu F, et al., 2020, Clinical diagnosis and treatment of spinal cord injury without evidence of abnormality in children: A review. Int Surg J, 7: 3847–3855. https://doi.org/10.18203/2349-2902.isj20204437

 

  1. Albuja AC, Qaiser S, Lightner DD, et al., 2017, Surfer’s myelopathy without surfing: A report of two pediatric patients. Spinal Cord Ser Cases, 3: 17008. https://doi.org/10.1038/scsandc.2017.8

 

  1. AbdelRazek MA, Mowla A, Farooq S, et al., 2016, Fibrocartilaginous embolism: A comprehensive review of an under-studied cause of spinal cord infarction and proposed diagnostic criteria. J Spinal Cord Med, 39: 146–154. https://doi.org/10.1080/10790268.2015.1116726

 

  1. Sidram V, Tripathy P, Ghorai SP, et al., 2009, Spinal cord injury without radiographic abnormality (SCIWORA) in children: A Kolkata experience. Indian J Neurotrauma, 6: 133–136. https://doi.org/10.1016/S0973-0508(09)80007-5

 

  1. Wang Y, Zhu F, Zeng L, et al., 2021, Surfer myelopathy in children: A case series study. World Neurosurg, 148: e227–e241. https://doi.org/10.1016/j.wneu.2020.12.135

 

  1. Martin BW, Dykes E, Lecky FE, 2004, Patterns and risks in spinal trauma. Arch Dis Child, 89: 860–865. https://doi.org/10.1136/adc.2003.029223

 

  1. Trigylidas T, Yuh SJ, Vassilyadi M, et al., 2010, Spinal cord injuries without radiographic abnormality at two pediatric trauma centers in Ontario. Pediatr Neurosurg, 46: 283–289. https://doi.org/10.1159/000320134

 

  1. Mahajan P, Jaffe DM, Olsen CS, et al., 2013, Spinal cord injury without radiologic abnormality in children imaged with magnetic resonance imaging. J Trauma Acute Care Surg, 75: 843–847. https://doi.org/10.1097/ta.0b013e3182a74abd

 

  1. Feng YP, Sun TS, Chen L, et al., 2017, Clinical therapeutic guideline for neurorestoration in spinal cord injury (Chinese version 2016). J Neurorestoratol, 5: 73–83. https://doi.org/10.2147/jn.s119581

 

  1. Huang H, Young W, Skaper S, et al., 2020, Clinical neurorestorative therapeutic guidelines for spinal cord injury (IANR/CANR version 2019). J Orthop Translat, 20: 14–24. https://doi.org/10.1016/j.jot.2019.10.006

 

  1. Farrell CA, Hannon M, Lee LK, 2017, Pediatric spinal cord injury without radiographic abnormality in the era of advanced imaging. Curr Opin Pediatr, 29: 286–290. https://doi.org/10.1097/MOP.0000000000000481

 

  1. Bosch PP, Vogt MT, Ward WT, 2002, Pediatric spinal cord injury without radiographic abnormality (SCIWORA): The absence of occult instability and lack of indication for bracing. Spine (Phila Pa 1976), 27: 2788–2800. https://doi.org/10.1097/00007632-200212150-00009

 

  1. Koestner AJ, Hoak SJ, 2001, Spinal cord injury without radiographic abnormality (SCIWORA) in children. J Trauma Nurs, 8: 101–108. https://doi.org/10.1097/00043860-200108040-00002

 

  1. Eckert MJ, Martin MJ, 2017, Trauma: Spinal cord injury. Surg Clin North Am, 97: 1031–1045. https://doi.org/10.1016/j.suc.2017.06.008

 

  1. Sharif S, Ali MY, 2020, Outcome prediction in spinal cord injury: Myth or reality. World Neurosurg, 140: 574–590. https://doi.org/10.1016/j.wneu.2020.05.043

 

  1. Fatehi D, Dayani MA, Rostamzadeh A, 2018, Role of CT scan in theranostic and management of traumatic spinal cord injury. Saudi J Biol Sci, 25: 739–746. https://doi.org/10.1016/j.sjbs.2016.08.004

 

  1. Ryken TC, Hadley MN, Walters BC, et al., 2013, Radiographic assessment. Neurosurgery, 72: 54–72. https://doi.org/10.1227/neu.0b013e318276edee

 

  1. Acheson MB, Livingston RR, Richardson ML, et al., 1987, High-resolution CT scanning in the evaluation of cervical spine fractures: Comparison with plain film examinations. AJR Am J Roentgenol, 148: 1179–1185. https://doi.org/10.2214/ajr.148.6.1179

 

  1. Zhang R, Zhou Z, Wu W, et al., 2018, An improved fuzzy connectedness method for automatic three-dimensional liver vessel segmentation in CT images. J Healthc Eng, 2018: 2376317. https://doi.org/10.1155/2018/2376317

 

  1. Feldman KW, Avellino AM, Sugar NF, et al., 2008, Cervical spinal cord injury in abused children. Pediatr Emerg Care, 24: 222–227. https://doi.org/10.1097/pec.0b013e31816b7aa4

 

  1. Sesmat H, Hayoun T, Bonnet J, et al., 2018, Spinal cord injury without radiographic abnormality (SCIWORA): About 3 cases and review of the literature. Biomed J Sci Tech Res, 8: 6208–6211.

 

  1. Matsumura A, Meguro K, Tsurushima H, et al., 1990, Magnetic resonance imaging of spinal cord injury without radiologic abnormality. Surg Neurol, 33: 281–283. https://doi.org/10.1016/0090-3019(90)90049-u

 

  1. Dreizin D, Kim W, Kim JS, et al., 2015, Will the real SCIWORA please stand up? Exploring clinicoradiologic mismatch in closed spinal cord injuries. AJR Am J Roentgenol, 205: 853–860. https://doi.org/10.2214/AJR.14.13374

 

  1. Schottler J, Vogel LC, Sturm P, 2012, Spinal cord injuries in young children: A review of children injured at 5 years of age and younger. Dev Med Child Neurol, 54: 1138–1143. https://doi.org/10.1111/j.1469-8749.2012.04411.x

 

  1. Reid S, Sell E, 2015, Case 2: Acute paralysis in a 10-year-old girl. Paediatr Child Health, 20: 289–290. https://doi.org/10.1093/pch/20.6.289a

 

  1. Pawar NH, Loke E, Aw DC, 2017, Spinal cord infarction mimicking acute transverse myelitis. Cureus, 9: e1911. https://doi.org/10.7759/cureus.1911

 

  1. Liao CC, Lui TN, Chen LR, et al., 2005, Spinal cord injury without radiological abnormality in preschool-aged children: Correlation of magnetic resonance imaging findings with neurological outcomes. J Neurosurg, 103: 17–23. https://doi.org/10.3171/ped.2005.103.1.0017

 

  1. Freigang V, Butz K, Seebauer CT, et al., 2021, Management and mid-term outcome after “real SCIWORA” in children and adolescents. Global Spine J, 12: 1208–1213. https://doi.org/10.1177/2192568220979131

 

  1. Zhu F, Liu Y, Zeng L, et al., 2021, Evaluating the severity and prognosis of acute traumatic cervical spinal cord injury: A novel classification using diffusion tensor imaging and diffusion tensor tractography. Spine (Phila Pa 1976), 46: 687–694. https://doi.org/10.1097/brs.0000000000003923

 

  1. Mulcahey MJ, Samdani AF, Gaughan JP, et al., 2013, Diagnostic accuracy of diffusion tensor imaging for pediatric cervical spinal cord injury. Spinal Cord, 51: 532–537. https://doi.org/10.1038/sc.2013.36

 

  1. Huien C, Jingsong S, Houhong C, et al., 2016, The application value of DTI imaging technology in spinal cord concussion injury. Chin J CT MRI, 14: 84. (Article in Chinese). https://doi.org/10.3969/j.issn.1672-5131.2016.10.010

 

  1. Alizadeh M, Fisher J, Saksena S, et al., 2018, Reduced field of view diffusion tensor imaging and fiber tractography of the pediatric cervical and thoracic spinal cord injury. J Neurotrauma, 35: 452–460. https://doi.org/10.1089/neu.2017.5174

 

  1. Zaninovich OA, Avila MJ, Kay M, et al., 2019, The role of diffusion tensor imaging in the diagnosis, prognosis, and assessment of recovery and treatment of spinal cord injury: A systematic review. Neurosurg Focus, 46: E7. https://doi.org/10.3171/2019.1.focus18591

 

  1. Copley PC, Tilliridou V, Kirby A, et al., 2019, Management of cervical spine trauma in children. Eur J Trauma Emerg Surg, 45: 777–789. https://doi.org/10.1007/s00068-018-0992-x

 

  1. Hadley MN, Walters BC, Aarabi B, et al., 2013, Clinical assessment following acute cervical spinal cord injury. Neurosurgery, 72: 40–53. https://doi.org/10.1227/NEU.0b013e318276edda

 

  1. Konovalov N, Peev N, Zileli M, et al., 2020, Pediatric cervical spine injuries and SCIWORA: WFNS spine committee recommendations. Neurospine, 17: 797–808. https://doi.org/10.14245/ns.2040404.202

 

  1. Fawcett JW, Curt A, Steeves JD, et al., 2007, Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: Spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials. Spinal Cord, 45: 190–205. https://doi.org/10.1038/sj.sc.3102007

 

  1. Zhu F, Zeng L, Gui S, et al., 2021, The role of diffusion tensor imaging and diffusion tensor tractography in the assessment of acute traumatic thoracolumbar spinal cord injury. World Neurosurg, 150: e23–e30. https://doi.org/10.1016/j.wneu.2021.01.146

 

  1. Atesok K, Tanaka N, O’Brien A, et al., 2018, Posttraumatic spinal cord injury without radiographic abnormality. Adv Orthop, 2018: 7060654. https://doi.org/10.1155/2018/7060654

 

  1. Stein DM, Sheth KN, 2015, Management of acute spinal cord injury. Continuum (Minneap Minn), 21: 159–187. https://doi.org/10.1212/01.con.0000461091.09736.0c

 

  1. Qi C, Xia H, Miao D, et al., 2020, The influence of timing of surgery in the outcome of spinal cord injury without radiographic abnormality (SCIWORA). J Orthop Surg Res, 15: 223. https://doi.org/10.1186/s13018-020-01743-1

 

  1. Grollmus J, Hoff J, 1975, Spontaneous spinal epidural haemorrhage: Good results after early treatment. J Neurol Neurosurg Psychiatry, 38: 89–90. https://doi.org/10.1136/jnnp.38.1.89

 

  1. Green E, Zishan US, Robertson N, et al., 2018, Non-traumatic myelopathy associated with prolonged hyperextension during swimming: An unusual variation of Surfer’s myelopathy. Spinal Cord Ser Cases, 4: 22. https://doi.org/10.1038/s41394-018-0055-x

 

  1. Fehlings MG, Tetreault LA, Wilson JR, et al., 2017, A clinical practice guideline for the management of patients with acute spinal cord injury and central cord syndrome: Recommendations on the timing (≤24 hours versus >24 hours) of decompressive surgery. Global Spine J, 7: 195S–202S. https://doi.org/10.1177/2192568217706367

 

  1. Kandziora F, Pingel A, 2017, Expert’s comment concerning grand rounds case entitled: “Increased intrathecal pressure after traumatic spinal cord injury: An illustrative case presentation and a review of the literature” by Grassner L, Winkler PA, Strowitzki M, et al.(Eur Spine J (2016). doi: 10.1007/s00586-016-4769-9) Surgical treatment of SICS (spinal intradural compartment syndrome)? Eur Spine J 26: 26–27. https://doi.org/10.1007/s00586-016-4804-x

 

  1. Yılmaz T, Kaptanoğlu E, 2015, Current and future medical therapeutic strategies for the functional repair of spinal cord injury. World J Orthop, 6: 42–55. https://doi.org/10.5312/wjo.v6.i1.42

 

  1. Tykocki T, Poniatowski Ł, Czyż M, et al., 2017, Intraspinal pressure monitoring and extensive duroplasty in the acute phase of traumatic spinal cord injury: A systematic review. World Neurosurg, 105: 145–152. https://doi.org/10.1016/j.wneu.2017.05.138

 

  1. Alizo G, Sciarretta JD, Gibson S, et al., 2018, Multidisciplinary team approach to traumatic spinal cord injuries: A single institution’s quality improvement project. Eur J Trauma Emerg Surg, 44: 245–250. https://doi.org/10.1007/s00068-017-0776-8

 

  1. Durojaiye AB, Levin S, Toerper M, et al., 2019, Evaluation of multidisciplinary collaboration in pediatric trauma care using EHR data. J Am Med Inform Assoc, 26: 506–515. https://doi.org/10.1093/jamia/ocy184

 

  1. Ellis MJ, McDonald PJ, Cordingley D, et al., 2016, Retirement-from-sport considerations following pediatric sports-related concussion: Case illustrations and institutional approach. Neurosurg Focus, 40: E8. https://doi.org/10.3171/2016.1.focus15600

 

  1. Knight PH, Maheshwari N, Hussain J, et al., 2015, Complications during intrahospital transport of critically ill patients: Focus on risk identification and prevention. Int J Crit Illn Inj Sci, 5: 256–264. https://doi.org/10.4103/2229-5151.170840

 

  1. Pal R, Agarwal A, Galwankar S, et al., 2014, The 2014 academic college of emergency experts in India’s INDO-US joint working group (JWG) white paper on “developing trauma sciences and injury care in India”. Int J Crit Illn Inj Sci, 4: 114–130. https://doi.org/10.4103/2229-5151.134151

 

  1. Kim SH, Yoon SH, Cho KH, et al., 2008, Spinal cord injury without radiological abnormality in an infant with delayed presentation of symptoms after a minor injury. Spine (Phila Pa 1976), 33: E792–E794. https://doi.org/10.1097/BRS.0b013e3181878719

 

  1. Panagopoulos D, 2018, A case of SCIWORA with uncommon combination of neurological and imaging findings. EC Paediatrics, 7: 498–506.

 

  1. Pang D, Pollack IF, 1989, Spinal cord injury without radiographic abnormality in children--the SCIWORA syndrome. J Trauma, 29: 654–664. https://doi.org/10.1097/00005373-198905000-00021

 

  1. Tolentino JC, Schadt J, Bird B, et al., 2018, Adverse events during intrahospital transfers: Focus on patient safety. In: Vignettes in Patient Safety-Volume 3. United Kingdom: IntechOpen. https://doi.org/10.5772/intechopen.76777

 

  1. Salt O, Akpınar M, Sayhan MB, et al., 2020, Intrahospital critical patient transport from the emergency department. Arch Med Sci, 16: 337–344. https://doi.org/10.5114/aoms.2018.79598

 

  1. Jiang B, 2015, The challenges faced in the field of trauma care in China. Zhonghua Wai Ke Za Zhi [Chin J Surg], 53: 401–404.

 

  1. Wang T, Yin X, Zhang P, et al., 2015, Road traffic injury and rescue system in China. Lancet, 385: 1622. https://doi.org/10.1016/S0140-6736(15)60794-2

 

  1. China Trauma Rescue and Treatment Association, 2017, Consensus on the establishment of urban trauma rescue system in China. Zhonghua Wai Ke Za Zhi, 55: 830–833. https://doi.org/10.3760/cma.j.issn.0529-5815.2017.11.002

 

  1. Silman E, Langdorf MI, Rudkin S, et al., 2008, Images in emergency medicine: Pediatric spinal cord injury without radiographic abnormality. West J Emerg Med, 9: 124.

 

  1. Nagasawa H, Ishikawa K, Takahashi R, et al., 2017, A case of real spinal cord injury without radiologic abnormality in a pediatric patient with spinal cord concussion. Spinal Cord Ser Cases, 3: 17051. https://doi.org/10.1038/scsandc.2017.51

 

  1. Kriss VM, Kriss TC, 1996, SCIWORA (spinal cord injury without radiographic abnormality) in infants and children. Clin Pediatr (Phila), 35: 119–124. https://doi.org/10.1177/000992289603500302

 

  1. Beck A, Gebhard F, Kinzl L, et al., 2000, Spinal cord injury without radiographic abnormalities in children and adolescents: Case report of a severe cervical spine lesion and review of literature. Knee Surg Sports Traumatol Arthrosc, 8: 186–189. https://doi.org/10.1007/s001670050212

 

  1. Bansal KR, Chandanwale AS, 2016, Spinal cord injury without radiological abnormality in an 8 months old female child: A case report. J Orthop Case Rep, 6: 8–10. https://doi.org/10.13107/jocr.2250-0685.363

 

  1. Ergun A, Oder W, 2003, Pediatric care report of spinal cord injury without radiographic abnormality (SCIWORA): Case report and literature review. Spinal Cord, 41: 249–253. https://doi.org/10.1038/sj.sc.3101442

 

  1. Hon EK, Chan J, Ng BK, et al., 2006, Spinal cord injury without radiographic abnormality (SCIWORA): A mere 50-cm fall that matters. Injury Extra, 37: 364–370. https://doi.org/10.1016/j.injury.2006.03.021

 

  1. Klakeel M, Thompson J, Srinivasan R, et al., 2015, Anterior spinal cord syndrome of unknown etiology. Proc (Bayl Univ Med Cent), 28: 85–87. https://doi.org/10.1080/08998280.2015.11929201

 

  1. Kalra V, Gulati S, Kamate M, et al., 2006, SCIWORA-spinal cord injury without radiological abnormality. Indian J Pediatr, 73: 829–831. https://doi.org/10.1007/BF02790395

 

  1. Kim C, Vassilyadi M, Forbes JK, et al., 2016, Traumatic spinal injuries in children at a single level 1 pediatric trauma centre: Report of a 23-year experience. Can J Surg, 59: 205–212. https://doi.org/10.1503/cjs.014515

 

  1. Sultan I, Lamba N, Liew A, et al., 2020, The safety and efficacy of steroid treatment for acute spinal cord injury: A systematic review and meta-analysis. Heliyon, 6: e03414. https://doi.org/10.1016/j.heliyon.2020.e03414

 

  1. Caruso MC, Daugherty MC, Moody SM, et al., 2017, Lessons learned from administration of high-dose methylprednisolone sodium succinate for acute pediatric spinal cord injuries. J Neurosurg Pediatr, 20: 567–574. https://doi.org/10.3171/2017.7.PEDS1756

 

  1. Fehlings MG, Wilson JR, Tetreault LA, et al., 2017, A clinical practice guideline for the management of patients with acute spinal cord injury: Recommendations on the use of methylprednisolone sodium succinate. Global Spine J, 7: 203S–211S. https://doi.org/10.1177/2192568217703085

 

  1. Mortazavi M, Gore PA, Chang S, et al., 2011, Pediatric cervical spine injuries: A comprehensive review. Childs Nerv Syst, 27: 705–717. https://doi.org/10.1007/s00381-010-1342-4

 

  1. Theodore N, Hadley MN, Aarabi B, et al., 2013, Prehospital cervical spinal immobilization after trauma. Neurosurgery, 72: 22–34. https://doi.org/10.1227/neu.0b013e318276edb1

 

  1. Rozzelle CJ, Aarabi B, Dhall SS, et al., 2013, Spinal cord injury without radiographic abnormality (SCIWORA). Neurosurgery, 72: 227–33. https://doi.org/10.1227/NEU.0b013e3182770ebc

 

  1. Brauge D, Plas B, Vinchon M, et al., 2020, Multicenter study of 37 pediatric patients with SCIWORA or other spinal cord injury without associated bone lesion. Orthop Traumatol Surg Res, 106: 167–171. https://doi.org/10.1016/j.otsr.2019.10.006

 

  1. Tatka J, Elbayer J, Vojdani S, et al., 2016, Pediatric spinal cord injury. J Spine, S7: 7. https://doi.org/10.4172/2165-7939.S7-007

 

  1. Sellin JN, Steele WJ 3rd, Simpson L, et al., 2016, Multicenter retrospective evaluation of the validity of the Thoracolumbar Injury Classification and Severity Score system in children. J Neurosurg Pediatr, 18: 164–170. https://doi.org/10.3171/2016.1.peds15663

 

  1. Santipas B, Wejjakul W, Luksanapruksa P, et al., 2020, Nonfusion muscle-sparing technique to treat long-segment thoracolumbar extradural arachnoid cyst in a child: A case report and review of the literature. World Neurosurg, 142: 222–226. https://doi.org/10.1016/j.wneu.2020.06.185

 

  1. Li G, Zhang Y, Zhao J, et al., 2016, Some cool considerations of external lumbar drainage during its widespread application in neurosurgical practice: A long way to go. Chin Neurosurg J, 2: 117–124. https://doi.org/10.1186/s41016-016-0033-8

 

  1. Zebracki K, Melicosta M, Unser C, et al., 2020, A primary care provider’s guide to pediatric spinal cord injuries. Top Spinal Cord Inj Rehabil, 26: 91–99. https://doi.org/10.46292/sci2602-91

 

  1. Fehlings MG, Tetreault LA, Wilson JR, et al., 2017, A clinical practice guideline for the management of acute spinal cord injury: Introduction, rationale, and scope. Global Spine J, 7: 84S–94S. https://doi.org/10.1177/2192568217703387

 

  1. Yalçınkaya EY, Saygı EK, Taşkıran ÖO, et al., 2021, Consensus recommendations for botulinum toxin injections in the spasticity management of children with cerebral palsy during COVID-19 outbreak. Turk J Med Sci, 51: 385–392. https://doi.org/10.3906/sag-2009-5

 

  1. Corti C, Urgesi C, Poggi G, et al., 2020, Home-based cognitive training in pediatric patients with acquired brain injury: Preliminary results on efficacy of a randomized clinical trial. Sci Rep, 10: 1391. https://doi.org/10.1038/s41598-020-57952-5

 

  1. Gandhi P, Chan K, Verrier MC, et al., 2017, Training to improve walking after pediatric spinal cord injury: A systematic review of parameters and walking outcomes. J Neurotrauma, 34: 1713–1725. https://doi.org/10.1089/neu.2016.4501

 

  1. Baharudin NS, Harun D, Kadar M, 2020, An assessment of the movement and function of children with specific learning disabilities: A review of five standardised assessment tools. Malays J Med Sci, 27: 21–36. https://doi.org/10.21315/mjms2020.27.2.3

 

  1. Xiaodong G, Yaping F, Tiansheng S, et al., 2021, Clinical guidelines for neurorestorative therapies in spinal cord injury (2021 China version). J Neurorestoratol, 9: 31–49. https://doi.org/10.26599/jnr.2021.9040003

 

  1. Chinese Association of Orthopedic Surgeons; Editorial Committee of the ‘Evidence-based Guideline for the Management of Acute Subaxial Cervical Spine Injury’ of Chinese Association of Orthopedic Surgeons, 2018, Evidence-based guideline for the management of acute subaxial cervical spine injury. Zhonghua Wai Ke Za Zhi 56: 5–9. (Articles in Chinese). https://doi.org/10.3760/cma.j.issn.0529-5815.2018.01.003

 

  1. Slotkin JR, Lu Y, Wood KB, 2007, Thoracolumbar spinal trauma in children. Neurosurg Clin N Am, 18: 621–630. https://doi.org/10.1016/j.nec.2007.07.003

 

  1. Wang Y, Zhang L, Pan G, et al., 2016, Traditional Chinese Medicine comprehensive therapy for the improvement of motor function in spinal cord injury patients. J Tradit Chin Med, 36: 618–624. https://doi.org/10.1016/s0254-6272(16)30081-4

 

  1. Zhang Q, Yang H, An J, et al., 2016, Therapeutic effects of traditional Chinese medicine on spinal cord injury: A promising supplementary treatment in future. Evid Based Complement Alternat Med, 2016: 8958721. https://doi.org/10.1155/2016/8958721

 

  1. Lu Y, Yang J, Wang X, et al., 2020, Research progress in use of traditional Chinese medicine for treatment of spinal cord injury. Biomed Pharmacother, 127: 110136. https://doi.org/10.1016/j.biopha.2020.110136

 

  1. Marinier M, Rodts MF, Connolly M, 1997, Spinal cord injury without radiographic abnormality (SCIWORA). Orthop Nurs, 16: 57–63; quiz 64–65. https://doi.org/10.1097/00006416-199709000-00015

 

  1. Martin-Rojas T, Sastre-Oliva T, Esclarín-Ruz A, et al., 2020, Effects of growth hormone treatment and rehabilitation in incomplete chronic traumatic spinal cord injury: Insight from proteome analysis. J Pers Med, 10: 183. https://doi.org/10.3390/jpm10040183

 

  1. Fiaschi P, Severino M, Ravegnani GM, et al., 2016, Idiopathic cervical hematomyelia in an infant: Spinal cord injury without radiographic abnormality caused by a trivial trauma? Case report and review of the literature. World Neurosurg, 90: 38–44. https://doi.org/10.1016/j.wneu.2016.01.094
Conflict of interest
All the authors declare no conflicts of interest.
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