AccScience Publishing / ITPS / Volume 6 / Issue 1 / DOI: 10.36922/itps.252
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REVIEW

Impact of COVID-19 Pandemic on Cancer Patients with Pulmonary Fibrosis on Chemosurveillance

Kiran R. Dudhat*
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1 Department of Pharmaceutics, School of Pharmacy, RK University, Kasturbadham, Rajkot, Gujarat, India
INNOSC Theranostics and Pharmacological Sciences 2023, 6(1), 15–21; https://doi.org/10.36922/itps.252
Submitted: 8 November 2022 | Accepted: 21 March 2023 | Published: 3 April 2023
© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

COVID-19 infection and multiplication can be regulated with the aid of vaccines, immunosurveillance, and antiviral medications, such interferon and nucleoside analogs. The main concern with COVID-19 infection is the proliferation of the virus. However, there is no medication to treat pulmonary fibrosis, a life-threatening condition, once it has manifested. To treat critically ill patients with cancer and pulmonary fibrosis, it is imperative to develop cell differentiation agent (CDA) formulations that can kill cancer stem cells. Chemosurveillance for cancer patients no longer functions as intended. As a result, people with cancer are more likely to experience severe symptoms of pulmonary fibrosis. The harm to chemosurveillance caused by cancer treatments that focus on cell death, such as cytotoxic drugs, radiation, and immunotherapy, may gravely accelerate the development of fatal pulmonary fibrosis. To prevent the development of fatal pulmonary fibrosis symptoms, cancer patients should be advised against contracting COVID-19, but, if they do, targeted therapy should be their first choice. The purpose of this study was to highlight the significance of chemosurveillance in determining when fatal pulmonary fibrosis manifests after COVID-19 infection in cancer patients and to conceptualize CDA formulations that can be used to treat both pulmonary fibrosis and cancer. COVID-19 infection causes biological and immunological reactions that are similar to those of a wound, leading to the production of prostaglandins and tumor necrosis factor, which cause respiratory illness symptoms, such as fever and cough, and cachexia symptoms, respectively. This results in the breakdown of chemosurveillance, a natural defense mechanism that ensures optimal wound healing, thus further promoting the development of cancer and pulmonary fibrosis.

Keywords
Cancer
COVID-19
Cell differentiation agent formulations
Chemosurveillance
Pulmonary fibrosis
Wound healing
Funding
None.
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Conflict of interest
The author declares no conflicts of interests.
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