AccScience Publishing / ITPS / Volume 4 / Issue 2 / DOI: 10.36922/itps.v4i2.215
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REVIEW

Effects of Medicinal Plants on Carbon Tetrachloride-Induced Liver Injury: A Review

Sayeed Mohammad Firdous1* Marwa A. A. Fayed2
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1 Department of Pharmacology, Calcutta Institute of Pharmaceutical Technology and Allied Health Sciences, Uluberia, Howrah, West Bengal, India
2 Department of Pharmacognosy, University of Sadat City, Sadat City32897, Egypt
INNOSC Theranostics and Pharmacological Sciences 2021 , 4(2), 23–32; https://doi.org/10.36922/itps.v4i2.215
Submitted: 10 October 2022 | Accepted: 27 December 2022 | Published: 13 January 2023
© 2021 by the Author(s). Licensee AccScience Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

The liver is the primary organ for metabolizing and eliminating foreign chemicals. When liver cells are exposed to large concentrations of dangerous substances, hepatocyte malfunction, membrane damage, and degradation may occur. Another chemical that can harm the liver is carbon tetrachloride (CCl4). CCl4 is converted into trichloromethyl radical [CCl3]- by several cytochrome P450 isoforms. [CCl3]- subsequently reacts with oxygen to generate trichloromethyl peroxyl radical [CCl3OO]- and induce lipid peroxidation in cell membranes. In this study, the mechanism by which a variety of recently identified medicinal plants display hepatoprotective activity against CCl4-induced liver injury is investigated. We find that animal models have been used in investigations of plant extracts. Herbal plants largely protect against CCl4-induced hepatotoxicity because their phytochemicals have an inhibitory nature. The antioxidant properties of phytochemicals can halt lipid oxidation and restrict the production of free radicals by inhibiting microsomal enzymes. They can also help liver cells in their fight against CCl4-induced inflammation by strengthening and fortifying them. The effectiveness of various herbs that are hepatoprotective and are thus plausible candidates for use in medicine must be confirmed. Experiments using entire plant extracts should be replaced with tests that pinpoint the active ingredients and assess the extracts’ effect on a variety of liver cell lines.

Keywords
Liver
Hepatocytes
Carbon tetrachloride
Medicinal plants
Hepatoprotective
Inflammation
Funding
None.
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Conflict of interest
No conflict of interest was declared by the authors.
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INNOSC Theranostics and Pharmacological Sciences, Electronic ISSN: 2705-0823, Print ISSN: TBA, Published by AccScience Publishing