AccScience Publishing / ITPS / Volume 2 / Issue 2 / DOI: 10.36922/itps.v2i2.545
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Formulation Development and In Vitro Release Studies of Tenofovir-containing Microsponges

Ravinder Naik Eslavath1 Vasudha Bakshi2 Rajendra Kumar Jadi2,3*
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1 Department of Pharmaceutics, St. Pauls College of Pharmacy, Turkayamjal, Hayathnagar, Rangareddy, Telangana, India
2 Department of Pharmaceutics, Anurag Group of Institutions, School of Pharmacy, Hyderabad, Telangana, India
3 Department of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana, India
INNOSC Theranostics and Pharmacological Sciences 2019, 2(2), 545
Submitted: 7 December 2018 | Accepted: 31 October 2019 | Published: 22 November 2019
© 2019 by the Authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( )

Background. Microsponges are intended to carry drugs with minimum dose, while delivering beneficial effects such as better drug stability and reduced adverse effects in recipients. The present investigation was aimed to develop and characterize microsponges containing tenofovir (TNF).
Methods. Quasi-emulsion diffusion technique was used to prepare TNF-containing microsponges. Eudragit L-100 was used as a polymer, whereas glycerol and dibutylphthalates were used as plasticizers. Drug and polymer were experimented in five formulations (F1-F5) of different ratios such as 1:1, 1:2, 1:3, 1:4, and 1:5. They were characterized for various physical parameters such as size, crystallinity, and interactions.
Results. Fourier-transform infrared spectroscopic results showed that there was no incompatibility between the drug and excipients. Drug entrapment efficacy was found between 47% and 67%, and the particle size ranges were between 4.52 µm and 8.98 µm. Cumulative drug diffusion of formulation F2 (drug:polymer ratio = 1:2) was found to be 84.15% in 180 min for an X-ray diffraction studies of pure drug and microsponges formulation clearly indicated the reduction in the crystallinity of the drug which could be the reason for the improved solubility of the drug. Scanning electron microscopy analysis results indicated that the formulations have excellent structure and almost all formulations exhibited in spherical shape.
Conclusion. Based on all the evaluation parameters, formulation F2 was concluded as the best formulation, and it is an alternative approach for conventional therapy with better patient compliance.

Cumulative drug release
X-ray diffraction studies
Scanning electron microscopy

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Conflict of interest
The authors declare that they have no conflicts of interest in any kind.
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INNOSC Theranostics and Pharmacological Sciences, Electronic ISSN: 2705-0823 Published by AccScience Publishing