AccScience Publishing / ITPS / Volume 2 / Issue 1 / DOI: 10.26689/itps.v2i1.550
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Formulation Development and In Vitro Characterization of Zolmitriptan Controlled Release Drug Delivery Systems

Shambhavi Pandala1 Vasudha Bakshi1 Rajendra Kumar Jadi2
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1 Department of Pharmaceutics, Anurag Group of Institutions, School of Pharmacy, Venkatapur, Medchal, Hyderabad, Telangana, India.
2 Department of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana, India.
INNOSC Theranostics and Pharmacological Sciences 2019, 2(1), 550
Submitted: 10 December 2018 | Accepted: 8 February 2019 | Published: 11 March 2019
© 2019 by the Authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( )

Background: Zolmitriptan is an artificial tryptamine, employed for the acute cure of migraine attack with or exclusive 
of aura and cluster headaches. Objective: It is an attempt to develop the extended release (ER) of Zolmitriptan matrix (ZMT) tablets to treat migraine safely and effectively.
Methods: All formulations were prepared with natural polymers or gums like guar gum, xanthan gum, karaya gum through direct compression method using 6mm punch. 
Results: Powder blend of all formulations (F1 - F12) using different ratios of the above mentioned gums (5%, 10%, 15% 
and 20%) were characterized with pre-compression parameters (angle of repose, bulk density, tapped density, compressibility index, hausner ratio, compatibility studies) and post-compression parameters (weight variation, thickness, friability, hardness, assay, in vitro dissolution studies). F1 - F4 formulations were prepared with gum karaya and compared with remaining gums; gum karaya shows more retardance capacity. F9 - F12 (with guar gum) formulations were unable to produce the desired release, whereas F5 - F8 formulations containing with xanthan gum exhibited more retarding effect with increasing concentration of polymer.
Conclusion: All prepared formulations (F1 - F12) were characterized and F3 formulation was optimized (97.3% drug released in 8 hours). All prepared formulations (F1 - F12) showed good flow properties and release patterns. Hence, formulations of ZMT matrix tablets have a promising delivery system which will enhance bio-availability and achieve greater therapeutic efficacy.

controlled release
direct compression
therapeutic efficacy

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Conflict of interest
The authors declare no conflict of interest.
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INNOSC Theranostics and Pharmacological Sciences, Electronic ISSN: 2705-0823 Published by AccScience Publishing