The lymphatic system plays critical roles in physiological processes, such as immunity, tissue fluid homeostasis, absorption of dietary lipids in the gut, and clearance of metabolites in the brain. Furthermore, it is implicated in the development of various pathologies, ranging from the spread of cancer to chronic inflammation and lymphoedema. Therefore, the design of reliable in vitro preclinical models is of fundamental importance to understand the mechanisms of lymphangiogenesis, as well as to test drugs capable of increasing or hindering it.

In the last decade, 3D bioprinting has emerged as a promising technology for the creation of complex organ-like structures using also microfluidic models. Nevertheless, 3D bioprinting has been rarely applied to lymphatic system development and physiology as well as pathology.

In this special issue, we welcome original multidisciplinary research and review articles that may contribute to filling this gap and increasing knowledge and discussion on this topic.