Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation

¹ State Key Laboratory of High-Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China

² Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China

³ Shenzhen Institute of Information Technology, Shenzhen 518172, China

⁴ The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, 410008, China

IJB 2020, 6(1), 248 https://doi.org/10.18063/ijb.v6i1.248

Published: 23 January 2020

© 2020 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

Fe is regarded as a promising bone implant material due to inherent degradability and high mechanical strength, but its degradation rate is too slow to match the healing rate of bone. In this work, hydrolytic expansion was cleverly exploited to accelerate Fe degradation. Concretely, hydrolyzable Mg2 Si was incorporated into Fe matrix through selective laser melting and readily hydrolyzed in a physiological environment, thereby exposing more surface area of Fe matrix to the solution. Moreover, the gaseous hydrolytic products of Mg2 Si acted as an expanding agent and cracked the dense degradation product layers of Fe matrix, which offered rapid access for solution invasion and corrosion propagation toward the interior of Fe matrix. This resulted in the breakdown of protective degradation product layers and even the direct peeling off of Fe matrix. Consequently, the degradation rate for Fe/Mg2 Si composites (0.33 mm/y) was significantly improved in comparison with that of Fe (0.12 mm/y). Meanwhile, Fe/Mg2 Si composites were found to enable the growth and proliferation of MG-63 cells, showing good cytocompatibility. This study indicated that hydrolytic expansion may be an effective strategy to accelerate the degradation of Fe-based implants.

Keywords

Hydrolytic expansion

Biodegradation

Fe-based implants

Selective laser melting

Cytocompatibility

References

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