AccScience Publishing / EJMO / Online First / DOI: 10.36922/ejmo.6606
ORIGINAL RESEARCH ARTICLE

Grain and legume consumption and risk of gastric cancer: Findings from a case–control study

Rana Youssef1 Dania Alsayyad1 Sarrah Daban1 Manar Adawi1 Sabika Allehdan2 Aya Hamdan1 Tareq Al-Jaberi3 Ahmad F. Hushki4 Yaser Rayyan5 Reema Tayyem1*
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1 Department of Human Nutrition, College of Health Sciences, QU Health University, Doha, Qatar
2 Department of Biology, College of Science, Sakhir Campus, University of Bahrain, Zallaq, Bahrain
3 Department of General & Pediatric Surgery, Faculty of Medicine University of Science and Technology, Irbid, Ar-Ramtha, Jordan
4 Gastroenterology Division, King Hussein Cancer Center, Amman, Jordan
5 Department of Gastroenterology and Hepatology, Faculty of Medicine, The University of Jordan, Amman, Jordan
Submitted: 27 November 2024 | Revised: 7 January 2025 | Accepted: 9 January 2025 | Published: 14 February 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

Gastric cancer (GC) is a leading cause of cancer-related mortality worldwide, with dietary factors significantly influencing GC risk. However, research on the dietary influences of GC in Middle Eastern populations, particularly in Jordan, remains limited. This study aimed to assess the association between the consumption of grains and legumes and GC risk in a Jordanian population, hypothesizing that refined grains may increase GC risk, while whole grains and legumes may offer protective effects. A case–control study was conducted involving 173 newly diagnosed GC cases and 314 cancer-free controls recruited from major hospitals in Jordan. Data were collected through interview-based questionnaires. Consumption of grains and legumes was assessed using a validated Arabic food frequency questionnaire tailored to Jordanian dietary habits. Statistical analyses were adjusted for key confounders to isolate the impact of dietary intake on GC risk. The findings indicate that a higher intake of refined grains, particularly white bread, is positively associated with an increased risk of GC, as shown by an odds ratio (OR) of 3.13 (confidence interval [CI]: 1.57 – 6.21, p = 0.001). In contrast, moderate rice consumption is linked to a reduced risk of GC (OR = 0.38, CI: 0.18 – 0.81). Legumes, including hummus (OR = 0.48, CI: 0.26 – 0.97) and cooked dried beans (OR = 0.40, CI: 0.20 – 0.81), were found to have protective associations with GC risk. However, the consumption of green peas was unexpectedly associated with an increased GC risk (OR = 2.19, CI: 1.24 – 3.88, p = 0.004), potentially due to preparation methods or consumption patterns. This study provides evidence linking specific grains and legumes to GC risk in Jordan. Refined grains appear to increase GC risk, while legumes may offer protective benefits. These findings underscore the importance of public health interventions that encourage increased consumption of legumes and discourage refined grain intake to mitigate GC risk in similar populations.

Keywords
Grains
Legumes
Gastric cancer
Case–control study
Funding
The authors would like to thank the Deanship of Scientific Research at Hashemite University for funding this research project. Open access funding is covered by Qatar University (Student Grant 2025 Cycle 1-CHS-203).
Conflict of interest
The authors declare that they have no conflict of interest.
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Eurasian Journal of Medicine and Oncology, Electronic ISSN: 2587-196X Print ISSN: 2587-2400, Published by AccScience Publishing