AccScience Publishing / EJMO / Online First / DOI: 10.36922/ejmo.6583
ORIGINAL RESEARCH ARTICLE

Clinical and demographic predictors of heart failure outcomes: A machine learning perspective

Shivaprasad Chitta1 Supriya Chandu2 Krishna Chaitanya Katha3 Syam Sundar Junapudi4 Vinod Kumar Yata5,6* Sunil Junapudi7*
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1 Department of Computer Science, Osmania University, Hyderabad, Telangana, India
2 Department of Public Health, College of Public Health, University of New Haven Brower Street, West Haven, Connecticut, United States of America
3 Bioinformatics and Computational Biology, Morsani College of Medicine, University of South Florida, Tampa, United States of America
4 Department of Community Medicine, Government Medical College, Mahabubabad, Telangana, India
5 Department of Molecular Biology, Central University of Andhra Pradesh, Anantapuramu, Andhra Pradesh, India
6 Research Centre, KBK Multispecialty Hospitals, Hyderabad, Telangana, India
7 Department of Pharmaceutical Chemistry, Geethanjali College of Pharmacy, Hyderabad, Telangana, India
Submitted: 27 November 2024 | Revised: 21 December 2024 | Accepted: 30 December 2024 | Published: 21 January 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

Heart failure (HF) is a multifaceted clinical condition associated with high morbidity and mortality rates. It is an increasing public health concern, impacting millions globally and placing considerable strain on healthcare systems. In recent decades, there has been a growing interest in using machine learning techniques to predict HF outcomes. Hence, this study aims to explore the clinical and demographic characteristics associated with HF outcomes using a comprehensive dataset obtained from Kaggle. The dataset, “Heart Failure Clinical Records.csv,” was preprocessed to address missing values and prepared for analysis. Feature importance analysis and correlation matrix computations were conducted to identify significant predictors of death events among HF patients, including age, serum creatinine, and ejection fraction. Various machine learning models, such as logistic regression, random forest, support vector machine, and gradient boosting machine, were employed to predict death events. The results revealed varying levels of performance among the models, with some demonstrating promising accuracy and predictive power. However, further refinement of these predictive models is warranted to enhance clinical decision-making and patient care in HF management. Overall, this study underscores the value of data-driven approaches in understanding HF outcomes and highlights the necessity for ongoing research in this field.

Graphical abstract
Keywords
Heart failure
Machine learning models
Logistic regression
Random forest
Support vector machine
Gradient boosting machine
Data-driven approaches
Funding
None.
Conflict of interest
The authors declare that they have no competing interests.
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Eurasian Journal of Medicine and Oncology, Electronic ISSN: 2587-196X Print ISSN: 2587-2400, Published by AccScience Publishing