The BMP14 +104T/C Polymorphism Provides Protection Against Susceptibility to Total Knee Arthroplasty: A Meta-Analysis and Trial Sequential Analysis
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Objectives: The link between the bone morphogenetic protein 14 (BMP14) +104T/C polymorphism and total knee arthroplasty (TKA) susceptibility has been previously studied with inconclusive findings. This research seeks to assess the association of the BMP14 +104T/C polymorphism with TKA predisposition.
Methods: A comprehensive search of databases such as PubMed, ResearchGate, Scopus, and CNKI was conducted up to September 01, 2023.
Results: Eight original studies involving 4,484 cases and 5,391 controls were reviewed. The findings indicate a protective effect of the BMP14 +104T/C variant against TKA susceptibility across all five genetic models: allele model (T vs. C: OR 0.856, 95% CI 0.805-0.911, p≤0.001, A), homozygote model (TT vs. CC: OR = 0.748, 95% CI 0.656-0.853, p≤0.001), dominant model (TT+TC vs. CC: OR = 0.855, 95% CI 0.705-0.975, p=0.020), and recessive model (TT vs. TC+CC: OR = 0.797, 95% CI 0.705-0.902, p≤0.001). Stratified analyses considering factors such as ethnicity, control source, country, and genotyping methods consistently revealed significant associations.
Conclusion: This finding suggests that individuals carrying the C allele of the BMP14 +104T/C polymorphism may have a lower chance of requiring TKA. These findings provide insights into the genetic factors that may influence the need for TKA and underscore the importance of further investigation in this area.
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