Association of MATN-3 and ADIPOQ Polymorphisms with Susceptibility to Knee Osteoarthritis

Ahmad Hashemzehi¹, Mohammadamin Ghadyani², Seyed Alireza Dastgheib³, Mohammed Reza Sobhan⁴, Sepideh Setayesh⁵, Seyedali Salari⁶, Masoud Zare-Shehneh⁷, Karim Daliri³, Hossein Neamatzadeh^6,7

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¹ Department of Pharmaceutics, Faculty of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran

² Department of Advanced Medical Sciences and Technologies, Islamic Azad University, Science and Research Branch, Tehran, Iran

³ Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

⁴ Department of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

⁵ Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

⁶ Department of Biology, Science and Arts University, Yazd, Iran

⁷ Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

⁸ Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

EJMO 2021, 5(4), 291–297; https://doi.org/10.14744/ejmo.2021.23898

Submitted: 31 July 2021 | Accepted: 28 September 2021 | Published: 1 December 2021

© 2021 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )

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Abstract

Objectives: The associations of Matrilin-3 (MATN3) and Adiponectin (ADIPOQ) polymorphisms with knee osteoarthritis (OA) risk have been reported, but it is currently the conclusions have been divergent. Thus, this study was performed to evaluate the association of MATN3 and ADIPOQ polymorphisms with susceptibility to knee OA.

Methods: We carried out this case-control study involving 105 cases with knee OA and 120 healthy subjects to evaluate the association of MATN3 rs8176070, ADI POQ rs1501299, rs822396, and rs2241766 polymorphisms with knee OA using RFLP-PCR assay.

Results: There was a significant association between MATN3 rs8176070 polymorphism and KOA risk. However, there was no significant association between rs1501299, rs822396, and rs2241766 polymorphisms at ADIPOQ gene and knee OA risk.

Conclusion: This piece of evidence revealed that the MATN3 rs8176070 polymorphism was serving as risk factor for development of knee OA, but not ADI POQ rs1501299, rs822396, and rs2241766 polymorphisms. However, well-designed and large-scale clinical studies are necessary to further validate our results.

Keywords

Adiponectin

Knee

MATN3

Osteoarthritis

Polymorphism.

Conflict of interest

None declared.

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