AccScience Publishing / EJMO / Volume 5 / Issue 1 / DOI: 10.14744/ejmo.2021.78845
Cite this article
1
Download
64
Views
Journal Browser
Volume | Year
Issue
Search
News and Announcements
View All
LETTER TO THE EDITOR

Neurotropism of SARS-CoV 2 and others Coronavirus in Children: Mechanisms and Clinical Manifestations

Silvia Marino1 Rosaria Taibi2 Piero Pavone3 Lidia Marino4 Raffaele Falsaperla5
Show Less
1 Unit of Pediatrics and Pediatric Emergency, Pediatric COVID-19 Center, AOU “Policlinico”, PO “San Marco”, University of Catania, Italy
2 Department of Medical Oncology, Istituto Nazionale Tumori, IRCCS, CRO, Aviano, Italy
3 Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Italy
4 Department of Clinical and Experimental Medicine, Postgraduate Training Programme in Pediatrics, University of Catania, Italy
5 Neonatal Intensive Care Unit [NICU], Neonatal COVID-19 Center, AOU “Policlinico”, PO “San Marco”, University of Catania, Italy
Submitted: 18 January 2021 | Accepted: 15 February 2021 | Published: 25 February 2021
© 2021 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Conflict of interest
None declared.
References

1.Li Q, Guan X, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. New Engl J Med 2020.

2. Lu R, Zhao X, Let al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020.

3. Zheng F, Liao C, Fan QH, Chen HB, Zhao XG, Xie ZG, et al. Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China. Curr Med Sci. 2020 Mar 24. [CrossRef]

4. Marino S, Ruggieri M, Falsaperla R. Is SARSCoV-2 nasopharyngeal swab still a gold standard in children? Med Hypotheses. 2020 Nov;144:110041. [CrossRef]

5. Pavone P, Marino S, Marino L, et al. Chilblains-like lesions and SARS-CoV-2 in children: An overview in therapeutic approach. Dermatol Ther. 2020 Nov 3:e14502. [CrossRef]

6. Quiroga MA, Cappuccio J, Piñeyro P, et al. Hemagglutinating encephalomyelitis coronavirus infection in pigs, Argentina. Emerg Infect Dis. 2008 Mar;14(3):484-6. [CrossRef]

7. St-Jean JR, Jacomy H, Desforges M, Vabret A, et al. Human respiratory coronavirus OC43: genetic stability and neuroinvasion. J Virol. 2004 Aug;78(16):8824-34. [CrossRef]

8. Dubé M, Le Coupanec A, Wong AHM, et al. Axonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43. J Virol. 2018 Aug 16;92(17). pii: e00404-18. [CrossRef]

9. Li YC, Bai WZ, Hirano N, et al. Coronavirus infection of rat dorsal root ganglia: ultrastructural characterization of viral replication, transfer, and the early response of satellite cells. Virus Res. 2012 Feb;163(2):628-35. [CrossRef]

10. Arbour N, Ekandé S, Côté G, et al. Persistent infection of human oligodendrocytic and neuroglial cell lines by human coronavirus 229E. J Virol. 1999 Apr;73(4):3326-37. [CrossRef]

11. Arbour N, Day R, Newcombe J, Talbot PJ. Neuroinvasion by human respiratory coronaviruses. J Virol. 2000 Oct;74(19):8913-21.

12. Bonavia A, Arbour N, Yong VW, et al. Infection of primary cultures of human neural cells by human coronaviruses 229E and OC43. J Virol. 1997 Jan;71(1):800-6. [CrossRef]

13. Bleau C, Filliol A, Samson M, et al. Brain Invasion by Mouse Hepatitis Virus Depends on Impairment of Tight Junctions and Beta Interferon Production in Brain Microvascular Endothelial Cells. J Virol. 2015 Oct;89(19):9896-908. [CrossRef]

14. Talbot PJ, Ekandé S, Cashman NR, et al. Neurotropism of human coronavirus 229E. Adv Exp Med Biol. 1993;342:339‐346.

15. Greig AS, Mitchell D, Corner AH, et al. A hemagglutinating virus producing encephalomyelitis in baby pigs. Can. J. Comp. Med. Vet. Sci. 26, 49–56. 1962

16. Gao W, Zhao K, Zhao C, et al. Vomiting and wasting disease associated with hemagglutinating encephalomyelitis viruses infection in piglets in Jilin, China. Virol J.2011 Mar 21;8:130. [CrossRef]

17. Yi Xu, Xufang Li, Bing Zhu, et al. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding Nature Medicine (2020).

18. Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020 Mar 7;395(10226):809-815. [CrossRef]

19. Kampfa G, Todtb D, et al. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J Hosp Infect 2020. [CrossRef]

20. Yanan Cao, Lin Li, Zhimin Feng, et al. Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations. Cell Discovery ( 2020) 6:11 Cell Discovery https://doi.org/10.1038/s41421-020-0147-1. [CrossRef]

21. Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. ACS Chem Neurosci. 2020 Apr 1;11(7):995-998. [CrossRef]

22. Winter PM, Dung NM, Loan HT, et al. Proinflammatory cytokines and chemokines in humans with Japanese encephalitis. J Infect Dis 2004; 190:1618–1626. [CrossRef]

23. Li Y, Li H, Fan R, et al. Coronavirus Infections in the Central Nervous System and Respiratory Tract Show Distinct Features in Hospitalized Children. Intervirology. 2016;59(3):163-169.

24. Dominguez SR, Robinson CC, Holmes KV. Detection of four human coronaviruses in respiratory infections in children: a oneyear study in Colorado. J Med Virol. 2009 Sep;81(9):1597-604.

25. Abdel-Mannan O, et al. Neurologic and Radiographic Findings Associated With COVID-19 Infection in Children. JAMA Neurol. 2020. PMID: 32609336. [CrossRef]

26. Paybast S, Gorji R, Mavandadi S. Guillain-Barre Syndrome as a Neurological Complication of Novel COVID-19 Infection: A Case Report and Review of the Literature. Neurologist. 2020 Jul;25(4):101-103. [CrossRef]

27. McAbee GN, Brosgol Y, Pavlakis S, et al.Encephalitis Associated with COVID-19 Infection in an 11-Year-Old Child. Pediatr Neurol. 2020 Aug;109:94. [CrossRef]

28. Yan CH, Faraji F, Prajapati DP, et al. Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms. Int Forum Allergy Rhinol. 2020 Jul;10(7):806-813. [CrossRef]

Share
Back to top
Eurasian Journal of Medicine and Oncology, Electronic ISSN: 2587-196X Print ISSN: 2587-2400, Published by AccScience Publishing