Recombinant Human Angiotensin-Converting Enzyme 2 and COVID-19 Acute Respiratory Distress Syndrome: A Theoretical or a Real Resource?

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LETTER TO THE EDITOR

Recombinant Human Angiotensin-Converting Enzyme 2 and COVID-19 Acute Respiratory Distress Syndrome: A Theoretical or a Real Resource?

Mirko Barone¹, Claudio Ucciferri^2,5, Giuseppe Cipollone^3,4, Felice Mucilli^3,4

¹ Department of General and Oncological Surgery, SS. Annunziata Hospital, Chieti, Italy

² Department of Infectious Diseases, SS. Annunziata Hospital, Chieti, Italy

³ Department of General and Thoracic Surgery, SS. Annunziata Hospital, Chieti, Italy

⁴ University Department of Medical, Oral and Biotechnological Sciences, Gabriele d’Annunzio University of Chieti-Pescara, Chieti, Italy

⁵ University Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy

EJMO 2020, 4(2), 139–140; https://doi.org/10.14744/ejmo.2020.47992

Submitted: 1 March 2020 | Accepted: 14 March 2020 | Published: 15 April 2020

© 2020 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )

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2. Wan Y, Shang J, Graham R, Baric RS, Li F. 2020. Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus. J Virol 2020;94:e00127–20. [CrossRef]

3. Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med 2005;11:875–9. [CrossRef]

4. Liu Y, Yang Y, Zhang C, et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Sci China Life Sci 2020;63:364–374. [CrossRef]

5. Khan A, Benthin C, Zeno B, et al. A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome. Crit Care 2017;21:234. [CrossRef]

6. Zhou F, Yu T, Du R, Fan G, Liu Y, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395:1054– 1062. [CrossRef]

7. Luo Y, Liu C, Guan T, et al. Association of ACE2 genetic polymorphisms with hypertension-related target organ damages in south Xinjiang. Hypertens Res 2019;42:681–9. [CrossRef]

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Eurasian Journal of Medicine and Oncology, Electronic ISSN: 2587-196X Print ISSN: 2587-2400, Published by AccScience Publishing