AccScience Publishing / EJMO / Volume 4 / Issue 2 / DOI: 10.14744/ejmo.2019.81104
RESEARCH ARTICLE

The Impacts of Covariates on Spatial Distribution of Corona Virus 2019 (COVID-19): What Do the Data Show through ANCOVA and MANCOVA?

Habte Tadesse Likassa1
Show Less
1 Department of Statistics, College of Natural and Computational Sciences, Ambo University, Shewa, Ethiopia
EJMO 2020, 4(2), 141–148; https://doi.org/10.14744/ejmo.2019.81104
Submitted: 16 March 2020 | Accepted: 10 April 2020 | Published: 15 April 2020
© 2020 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

Objectives: In late December 2019, a group of cases with 2019 Novel Coronavirus pneumonia (SARS-COV-2) in Wuhan, China, raised worldwide concern. This novel virus is turning into a global nightmare and a serious health problem. Even though an accurate estimate of the case-fatality risk is difficult; this research is useful to mitigate the spatial pattern of COVID-19. In this study, we aim to assess the impacts of covariates (age, sex, blood type, and disease severity, patients’ previous health history , transmission type, and location) on the spatial distribution of COVID-19.

Methods: Relevant data were obtained from the World Health Organization released by March 18, 2020 and some other information from published studies were taken into consideration. The data were analyzed using descriptive statistics, t-test, Analysis of Covariance (ANCOVA) and Multivariate Analysis of Covariance (MANCOVA) through STATA packages.

Results: The spatial pattern of COVID-19 is varying with more than a half-million confirmed cases and thousands of deaths worldwide. . The result of the study has also shown that the spatial pattern of COVID-19 is fluctuating and reflected the large confirmed cases and deaths of the Republic of China, Italy, USA and Iran. There is also evidence that age and population density variation has a statistically significant association with deaths due to COVID-19 (Fcal=133.909 and P-value= 0.000*). The result also highlighted a statistically significant difference between male and female patients affected by COVID-19. The infection fatality rate in 0-9 years is almost nonexistent; whereas for patients over the age of 50 it is relatively suffering.. There is also statistical evidence of the outbreak of the epidemic that in Europe, America and the Western Pacific Region the local transmission is predominant, while in Africa and in other regional areas most cases are fugitive. Despite some variation in initial symptoms, most COVID-19 patients have a fever and respiratory symptoms. Social distancing and special 

Keywords
COVID-19
covariates
spatial distribution
transmission and MANCOVA
Conflict of interest
None declared.
References

1.Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. Int J Antimicrobial Agents. 2020 Feb 17:105924. doi: 0.1016/j. ijantimicag.2020.105924. [Epub ahead of print].

2. Wang LS, Wang YR, Ye DW, Liu QQ. A review of the 2019 Novel Coronavirus (COVID-19) based on current evidence”. Int J Antimicrob Agents. 2020 [Epub ahead of print].

3. WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020. [https://www.who.int/dg/ speeches/detail/who-director-general-s-opening-remarks-at the-media-briefing-on-covid-19---11-march-2020].

4. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020 Feb 24. doi: 10.1001/jama.2020.2648. [Epub ahead of print]

5. Santé Publique France. Infection au nouveau Coronavirus (SARS-CoV-2), COVID-19, France et Monde [https://www.santepubliquefrance.fr/maladies-et-raumatismes/maladies-et infections-respiratoires/infection-a-coronavirus/articles/infection-au-nouveau-coronavirussars-cov-2-covid-19-franceet-monde]

6. Colson P, Rolain JM, Raoult D. Chloroquine for the 2019 novel coronavirus SARS-CoV2. Int J Antimicrob Agents. 2020 Feb 15:105923. doi: 10.1016/j.ijantimicag.2020.105923. [Epub ahead of print].

7. Colson P, Rolain JM, Lagier JC, Brouqui P, Raoult D. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int J Antimicrob Agents. 2020 [Epub ahead of print].

8. Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 2020;10-0282.

9. Gao J, Tian Z, Yang X. Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Biosci Trends 2020 Feb 19. doi: 10.5582/bst.2020.01047. [Epub ahead of print].

11. Multicenter collaboration group of Department of Science and Technology of Guangdong Province and Health Commission of Guangdong Province for chloroquine in the treatment of novel coronavirus pneumonia. Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia]. Zhonghua Jie He He Hu Xi Za Zhi 2020;43:185-8.

12. Philippe Gautret, Jean-Christophe Lagier and Didier Raoult[2020]: Hydroxychloroquine And Azithromycin As A Treatment Of COVID-19: Results of An Open Label Non-Randomized Clinical Trial.

13. Age, Sex, Existing Conditions of COVID-19 Cases and Deaths.

14. Katelyn Gostic , Ana CR Gomez, Riley O Mummah, Adam J Kucharski, James O Lloyd-Smith (2020): Estimated effectiveness of symptom and risk screening to prevent the spread of COVID-19.

15. Giovanetti M, Benvenuto D, Angeletti S, Ciccozzi M. The first two cases of 2019-nCoV in Italy: Where they come from? J Med Virol. 2020; [Epub ahead of print].PubMedExternal Link

16. Centers for Disease Control and Prevention. Coronavirus disease 2019 (COVID-19) in the U.S. [cited 2020 Feb 21].https:// www.cdc.gov/coronavirus/2019-ncov/cases-in-us.html 

17. Rothe C, Schunk M, Sothmann P, Bretzel G, Froeschl G, Wallrauch C, et al. Transmission of 2019-nCoV infection from an asymptomatic contact in Germany. N Engl J Med. 2020;382:970– 1.PubMedExternal Link

18. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; pii: S0140-6736(20)30183-5. https://doi.org/10.1016/ S0140-6736(20)30183-5. [Epub ahead of print]

19. Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia inWuhan, China: a descriptive study. Lancet. 2020; pii: S0140-6736(20)30211-7. https:// doi.org/10.1016/S0140- 6736(20)30211-7. [Epub ahead of print]

20. Li Q, Guan X, Wu P, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med. 2020;https://doi.org/10.1056/NEJMoa2001316. [Epub ahead of print]

21. Song F, Shi N, Shan F, et al. Emerging Coronavirus 2019- nCoV Pneumonia. Radiology. 2020; 6:200274. https://doi. org/10.1148/radiol.2020200274. [Epub ahead of print]

22. Chen L, Liu HG, Liu W, et al. Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia.

23. Zhonghua Jie He He Hu Xi Za Zhi. 2020;43 (0):E005. https:// doi.org/10.3760/cma.j.issn.1001-0939. 2020.0005. [Epub ahead of print]

24. Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020. https://doi.org/10.1001/ jama.2020.1585. [Epubahead of print]

25. Fang Jiang, Liehua Deng, Liangqing Zhang, YinCai1, Chi Wai Cheung, and Zhengyuan Xia [2020]: Review of the Clinical Characteristics of Coronavirus Disease 2019 (COVID-19)

26. Jiao Zhao, Yan Yang, Han-Ping Huang, Dong Li, Dong-Feng Gu,Xiang-Feng Lu, Zheng Zhang, Lei Liu, Ting Liu, Yu-Kun Liu, Yun-Jiao He, Bin Sun, Mei-Lan Wei, Yi-Rong Li, Guang-Yu Yang , Xing-Huan Wang9 , Li Zhang, Xiao-Yang Zhou, Mingzhao Xing, Peng George Wang: Relationship between the ABO Blood Group and the COVID-19 Susceptibility(2020).

Share
Back to top
Eurasian Journal of Medicine and Oncology, Electronic ISSN: 2587-196X Print ISSN: 2587-2400, Published by AccScience Publishing