AccScience Publishing / CP / Online First / DOI: 10.36922/cp.4987
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ORIGINAL RESEARCH ARTICLE

Association of Mitochondrial ribosomal protein S33 expression with poor prognosis in glioma

Zhongmin Li1 ,  Xinxing Wang1 ,  Qiang Li1 ,  Xiangyang Wang1 ,  Xinmin Ding1*
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1 Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
CP, 4987 https://doi.org/10.36922/cp.4987
Received: 29 September 2024 | Revised: 1 April 2025 | Accepted: 7 April 2025 | Published online: 28 May 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Despite advancements in diagnostic and therapeutic strategies, early detection and improved prognosis of gliomas remain challenging. A deeper understanding of glioma pathogenesis and the identification of reliable biomarkers are crucial for early diagnosis and the reduction of healthcare costs. Mitochondrial ribosomal protein S33 (MRPS33), a key component of mitochondrial protein synthesis, has not been well-characterized in terms of its expression profile, prognostic significance, and immunological relevance in glioma. This study aims to elucidate these aspects through bioinformatics analyses utilizing data from The Cancer Genome Atlas, Genotype-Tissue Expression Project, and Tumor Immune Estimation Resource databases through the Sangerbox platform. Our results indicate a pronounced upregulation of MRPS33 in glioma tissues, which is significantly associated with poor prognosis, heightened immune cell infiltration, and differential drug sensitivities. Furthermore, functional enrichment analyses suggest that MRPS33 is intricately involved in several key biological processes, thereby underscoring its potential role in glioma pathophysiology. In conclusion, our findings support the potential of MRPS33 as a prognostic biomarker and therapeutic target in glioma, providing insights that may advance our understanding of disease mechanisms and inform future clinical strategies.

Keywords
MRPS33
Glioma
Prognosis
Immune cell infiltration
Funding
This study was supported by the Clinical Key Specialty Program of Shanxi Bethune Hospital and grants from the Shanxi Provincial Basic Research Program (201901D1478).
Conflict of interest
The authors declare that they have no competing interests.
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