Primary Small-Cell Neuroendocrine Carcinoma of the Kidney with Urothelial Carcinoma: A Case Series and Literature Review
Primary small-cell neuroendocrine carcinoma of the kidney with urothelial carcinoma is very rare, and it has a unique pathomorphology and immunohistochemical phenotype. Since it is easily missed diagnosed or misdiagnosed, it needs to be differentiated from a variety of other tumors. In addition to poor prognosis, the carcinoma also has strong invasive ability. The clinicopathological characteristics, immunohistochemical phenotype, and diagnosis and differential diagnosis of four patients with primary small-cell neuroendocrine carcinoma with urothelial carcinoma were retrospectively analyzed, and the relevant literature was reviewed. Three cases occurred in the left kidney and one case occurred in the right kidney. The main clinical symptoms were gross hematuria and waist pain. Tumor histological morphology and immunohistochemical markers support small-cell neuroendocrine carcinoma with urothelial carcinoma.
Bui M, Khalbuss WE, 2005, Primary Small Cell Neuroendocrine Carcinoma of the Urinary Bladder with Coexisting High-grade Urothelial Carcinoma: A Case Report and a Review of the Literature. CytoJournal, 2:18. DOI: 10.4103/0970-1591.44273.
Banerji JS, Anila K, Panicker JB, 2008, Multicentric Small Cell Neuroendocrine Neoplasm of the Renal Pelvis and Ureter with Concomitant Focal High-grade Urothelial Carcinoma of the Ureter: A Case Report. Indian J Urol, 24 :571–4.
Wang X, Wang F, Liang Y, 2018, Primary Small Cell Carcinoma after Renal Transplant: A Case Report. Medicine, 97:e12592. DOI: 10.1097/md.0000000000012592.
Rosa SL, Bernasconi B, Micello D, et al., 2009, Primary Small Cell Neuroendocrine Carcinoma of the Kidney: Morphological, Immunohistochemical, Ultrastructural, and Cytogenetic Study of a Case and Review of the Literature. Endocr Pathol, 20:24–34. DOI: 10.1007/s12022-008-9054-y.
Lane BR, Jour G, Zhou M, 2009, Renal Neuroendocrine Tumors. Indian J Urol, 25:155–60.
Romero FR, Soroush RB, Sompol P, et al., 2006, Primary Carcinoid Tumors of the Kidney. J Urol, 176:2359–66.
Liu S, Hua X, Zhu H, 2014, Primary Small Cell Carcinoma of the Renal Pelvis with Adenocarcinoma Component. Indian J Pathol Microbiol, 57:154–5. DOI: 10.4103/0377-4929.130935.
Yeung HM, Jeurkar C, Pompa T, 2017, Small Cell Cancer of the Genitourinary Tract: A Case Report and Review of the Literature. Case Rep Oncol, 10:489–92. DOI: 10.1159/000477435.
Dores GM, Qubaiah O, Mody A, et al., 2015, A Population-based Study of Incidence and Patient Survival of Small Cell Carcinoma in the United States, 1992–2010. BMC Cancer, 15:1–10. DOI: 10.1186/s12885-015-1188-y.
Trias I, Algaba F, Condom E, et al., 2001, Small Cell Carcinoma of the Urinary Bladder. Presentation of 23 Cases and Review of 134 Published Cases. Eur Urol, 39:85–90.
Moukassa D, Leroy X, Bouchind’Homme B, et al., 2000, Primary Large Cell Neuroendocrine Carcinoma of the Kidney: Morphologic and Immunohistochemical Features of Two Cases. Ann Pathol, 20:357–60.