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The gut microbiota and associated metabolites in multiple sclerosis

Yunshu Wang1 ,  Zihao Li2 ,  Yun Xu2 ,  Cun-Jin Zhang1,2*
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1 Department of Basic Research, Medical School of Nanjing University, Nanjing, Jiangsu, China
2 Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, Jiangsu, China
Advanced Neurology 2023, 2(3), 413 https://doi.org/10.36922/an.413
Submitted: 30 March 2023 | Accepted: 10 July 2023 | Published: 26 July 2023
© 2023 by the Author (s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Multiple sclerosis (MS) is a severe central nervous system autoimmune inflammatory disease featured by the presence of infiltrated immune cells, demyelination, and degeneration. Recent research has shown that gut microbiota, including some commensal bacteria, is capable of interacting with the host immune system and remarkably influencing the development and outcome of experimental autoimmune encephalomyelitis, a classic animal model of MS. In addition, gut dysbiosis, presented with a significantly altered composition of commensal bacteria, is linked to the immune response and inflammation, such as Th17 activation and B cell function. Moreover, it has been observed that microbiota impacts the immune system by regulating the metabolites in the gut. In this review, we summarize the new research on the relationship and mechanism between the gut microbiota and MS, as well as the implications for developing new strategies in MS by modulating the gut microbiota and metabolites.

Keywords
Gut
Microbiota
Metabolites
Multiple sclerosis
Inflammation
Funding
National Natural Science Fund for Excellent Young Scholars
Nanjing special fund for Medical Science and Technology Development Projects for Distinguished Young Scholars
National Natural Science Foundation of China
The Fundamental Research Funds for the Central Universities the Key Research
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Conflict of interest
The authors declare that they have no competing interests.
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Advanced Neurology, Electronic ISSN: 2810-9619 Published by AccScience Publishing
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