Secondary analysis of published data on selenium nanoparticles for heavy metal remediation: Exploratory evidence on synthesis route, particle size, and reported performance
Selenium nanoparticles (SeNPs) are emerging as promising agents for the remediation of heavy metal contamination due to their high surface reactivity and removal efficiency. In this study, secondary quantitative data derived from a screened set of 20 published source studies were evaluated, with a smaller subset of sufficiently comparable studies retained for direct exploratory analysis. The reported performance patterns were compared using descriptive statistics, correlation analysis, and regression analysis. The results show that smaller nanoparticles tended to have a higher removal efficiency and adsorption capacity, whereas biogenic and green synthesis routes tended to show relatively better performance compared with plant-based and physical methods. Regression outcomes also indicated a strong negative correlation between nanoparticle size and remediation performance. Nonetheless, the results obtained are early findings, since the set of observations is too small and represents a heterogeneous sample of laboratory investigations, using varied types of heavy metals and exposure conditions. Overall, this study highlights the role of the synthesis pathway and particle size in the documented bioremediation of SeNPs.
- Dhaliwal SS, Singh J, Taneja PK, Mandal A. Remediation techniques for removal of heavy metals from the soil contaminated through different sources: a review. Environ Sci Pollut Res. 2019;27(2):1319-1333. doi: 10.1007/s11356-019-06967-1
- Abd Elnabi MK, Elkaliny NE, Elyazied MM, et al. Toxicity of Heavy Metals and Recent Advances in Their Removal: A Review. Toxics. 2023;11(7):580. doi: 10.3390/toxics11070580
- Wang L, Rinklebe J, Tack FMG, Hou D. A review of green remediation strategies for heavy metal contaminated soil. Soil Use Manage. 2021;37(4):936-963. doi: 10.1111/sum.12717
- Hama Aziz KH, Mustafa FS, Omer KM, Hama S, Hamarawf RF, Rahman KO. Heavy metal pollution in the aquatic environment: efficient and low-cost removal approaches to eliminate their toxicity: a review. RSC Adv. 2023;13(26):17595-17610. doi: 10.1039/d3ra00723e
- Rashid A, Schutte BJ, Ulery A, et al. Heavy Metal Contamination in Agricultural Soil: Environmental Pollutants Affecting Crop Health. Agronomy. 2023;13(6):1521. doi: 10.3390/agronomy13061521
- Wan Y, Liu J, Zhuang Z, Wang Q, Li H. Heavy Metals in Agricultural Soils: Sources, Influencing Factors, and Remediation Strategies. Toxics. 2024;12(1):63. doi: 10.3390/toxics12010063
- Rajendran S, Priya TAK, Khoo KS, et al. A critical review on various remediation approaches for heavy metal contaminants removal from contaminated soils. Chemosphere. 2022;287:132369. doi: 10.1016/j.chemosphere.2021.132369
- Saha L, Tiwari J, Bauddh K, Ma Y. Recent Developments in Microbe–Plant-Based Bioremediation for Tackling Heavy Metal-Polluted Soils. Front Microbiol. 2021;12. doi: 10.3389/fmicb.2021.731723
- Jacob JM, Karthik C, Saratale RG, et al. Biological approaches to tackle heavy metal pollution: A survey of literature. J Environ Manage. 2018;217:56-70. doi: 10.1016/j.jenvman.2018.03.077
- Cai C, Zhao M, Yu Z, Rong H, Zhang C. Utilization of nanomaterials for in-situ remediation of heavy metal(loid) contaminated sediments: A review. Sci Total Environ. 2019;662:205-217. doi: 10.1016/j.scitotenv.2019.01.180
- Malik S, Kumar D. Perspectives of nanomaterials in microbial remediation of heavy metals and their environmental consequences: A review. Biotechnol Genet Eng Rev. 2023;40(1):154-201. doi: 10.1080/02648725.2023.2182546
- Zohra E, Ikram M, Omar AA, et al. Potential applications of biogenic selenium nanoparticles in alleviating biotic and abiotic stresses in plants: A comprehensive insight on the mechanistic approach and future perspectives. Green Process Synth. 2021;10(1):456-475. doi: 10.1515/gps-2021-0047
- Zou Y, Wang X, Khan A, et al. Environmental Remediation and Application of Nanoscale Zero-Valent Iron and Its Composites for the Removal of Heavy Metal Ions: A Review. Environ Sci Technol. 2016;50(14):7290-7304. doi: 10.1021/acs.est.6b01897
- Chen N, Yao P, Zhang W, et al. Selenium nanoparticles: Enhanced nutrition and beyond. Crit Rev Food Sci Nutr. 2022;63(33):12360-12371. doi: 10.1080/10408398.2022.2101093
- Hussain A, Lakhan MN, Hanan A, et al. Recent progress on green synthesis of selenium nanoparticles: a review. Mater Today Sustain. 2023;23:100420. doi: 10.1016/j.mtsust.2023.100420
- Mikhailova EO. Selenium Nanoparticles: Green Synthesis and Biomedical Application. Molecules. 2023;28(24):8125. doi: 10.3390/molecules28248125
- Yu S, Liu H, Yang R, Zhou W, Liu J. Aggregation and stability of selenium nanoparticles: Complex roles of surface coating, electrolytes and natural organic matter. J Environ Sci. 2022;130:14-23. doi: 10.1016/j.jes.2022.10.025
- Li K, Li J, Zhang S, et al. Amorphous Structure and Crystal Stability Determine the Bioavailability of Selenium Nanoparticles. J Hazard Mater. 2024;465:133287. doi: 10.1016/j.jhazmat.2023.133287
- Sharma P, Pandey AK, Kim SH, Singh SP, Chaturvedi P, Varjani S. Critical review on microbial community during in-situ bioremediation of heavy metals from industrial wastewater. Environ Technol Innov. 2021;24:101826. doi: 10.1016/j.eti.2021.101826
- Mishra S, Lin Z, Pang S, Zhang Y, Bhatt P, Chen S. Biosurfactant is a powerful tool for the bioremediation of heavy metals from contaminated soils. J Hazard Mater. 2021;418:126253. doi: 10.1016/j.jhazmat.2021.126253
- Raklami A, Meddich A, Oufdou K, Baslam M. Plants— Microorganisms-Based Bioremediation for Heavy Metal Cleanup: Recent Developments, Phytoremediation Techniques, Regulation Mechanisms, and Molecular Responses. Int J Mol Sci. 2022;23(9):5031. doi: 10.3390/ijms23095031
- Ojuederie O, Babalola O. Microbial and Plant-Assisted Bioremediation of Heavy Metal Polluted Environments: A Review. Int J Environ Res Public Health. 2017;14(12):1504. doi: 10.3390/ijerph14121504
- Yuan Z, Cai S, Yan C, Rao S, Liu X. Research Progress on the Physiological Mechanism by Which Selenium Alleviates Heavy Metal Stress in Plants: A Review. Agronomy. 2024;14(8):1787. doi: 10.3390/agronomy14081787
- El-Saadony MT, Saad AM, Alkafaas SS, et al. Selenium nanoparticles: Eco-friendly synthesis, biological activities and biomedical applications - A comprehensive review. Mater Today Bio. 2026;37:102946. doi: 10.1016/j.mtbio.2026.102946
- Sampath S, Sunderam V, Manjusha M, Dlamini Z, Lawrance AV. Selenium Nanoparticles: A Comprehensive Examination of Synthesis Techniques and Their Diverse Applications in Medical Research and Toxicology Studies. Molecules. 2024;29(4):801. doi: 10.3390/molecules29040801
- Zhang T, Qi M, Wu Q, Xiang P, Tang D, Li Q. Recent research progress on the synthesis and biological effects of selenium nanoparticles. Front Nutr. 2023;10. doi: 10.3389/fnut.2023.1183487
- Zhou P, Adeel M, Shakoor N, et al. Application of Nanoparticles Alleviates Heavy Metals Stress and Promotes Plant Growth: An Overview. Nanomaterials. 2020;11(1):26. doi: 10.3390/nano11010026
- Korde P, Ghotekar S, Pagar T, Pansambal S, Oza R, Mane D. Plant Extract Assisted Eco-benevolent Synthesis of Selenium Nanoparticles- A Review on Plant Parts Involved, Characterization and Their Recent Applications. J Chem Rev. 2020;2(3):157-168.doi: 10.22034/jcr.2020.106601
- Pyrzynska K, Sentkowska A. Biosynthesis of selenium nanoparticles using plant extracts. J Nanostruct Chem. 2021;12(4):467-480. doi: 10.1007/s40097-021-00435-4
- Ranjitha VR, Rai VR. Selenium nanostructure: Progress towards green synthesis and functionalization for biomedicine. J Pharm Investig. 2021;51(2):117-135. doi: 10.1007/s40005-020-00510-y
- Wickham R. Secondary Analysis research. J Adv Pract Oncol. 2020;10(4):395-400. doi: 10.6004/jadpro.2019.10.4.7
- Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi: 10.1136/bmj.n71
- Cole AP, Trinh QD. Secondary data analysis. Curr Opin Urol. 2017;27(4):354-359. doi: 10.1097/mou.0000000000000407
- Zhou Z, Dong Y, Zhu L, et al. Effective and stable adsorptive removal of Cadmium(II) and Lead(II) using selenium nanoparticles modified by microbial SmtA metallothionein. Chemosphere. 2022;307:135818. doi: 10.1016/j.chemosphere.2022.135818
- Ran M, Wu J, Jiao Y, Li J. Efficient removal of Sb(III) from wastewater using selenium nanoparticles synthesized by Psidium guajava plant extract. Environ Sci Pollut Res. 2024;31(31):43781-43797. doi: 10.1007/s11356-024-34007-0
- Amde M, Yao J, Liu JF, Tan ZQ. Nano-selenium functionalized zinc oxide nanorods: A superadsorbent for mercury (II) removal from waters. J Hazard Mater. 2020;392:122495. doi: 10.1016/j.jhazmat.2020.122495
- Darwesh OM, Matter IA, Abdel-Maksoud MA, et al. Development of nanocomposite-selenium filter for water disinfection and bioremediation of wastewater from Hg and AgNPs. Sci Rep. 2024;14(1). doi: 10.1038/s41598-024-70120-3
- Golgoli T, Ghanemi K, Buazar F. Cysteine-functionalized selenium nanoparticles for efficient extraction and preconcentration of cadmium, copper, lead, and zinc ions from environmental water samples. J Mol Liq. 2023;393:123680. doi: 10.1016/j.molliq.2023.123680
- Jain R, Jordan N, Schild D, et al. Adsorption of zinc by biogenic elemental selenium nanoparticles. Chem Eng J. 2015;260:855-863. doi: 10.1016/j.cej.2014.09.057
- Sinharoy A, Kumar M, Chaudhuri R, Saikia S, Pakshirajan K. Simultaneous removal of selenite and heavy metals from wastewater and their recovery as nanoparticles using an inverse fluidized bed bioreactor. J Clean Prod. 2022;376:134248. doi: 10.1016/j.jclepro.2022.134248
- Zangmo T, Siripinyanond A. Exploring the applicability of nano-selenium for capture of mercury vapor: Paper based sorbent and a chemical modifier in graphite furnace atomic absorption spectrometry. Anal Chim Acta. 2019;1085:29-38. doi: 10.1016/j.aca.2019.08.021
- Sinharoy A, Saikia S, Pakshirajan K. Biological removal of selenite from wastewater and recovery as selenium nanoparticles using inverse fluidized bed bioreactor. J Water Process Eng. 2019;32:100988. doi: 10.1016/j.jwpe.2019.100988
- Won S, Ha MG, Nguyen DD, Kang HY. Biological selenite removal and recovery of selenium nanoparticles by haloalkaliphilic bacteria isolated from the Nakdong River. Environ Pollut. 2021;280:117001. doi: 10.1016/j.envpol.2021.117001
- Yan S, Cheng KY, Ginige MP, et al. Sequential removal of selenate, nitrate and sulfate and recovery of elemental selenium in a multi-stage bioreactor process with redox potential feedback control. J Hazard Mater. 2022;424:127539. doi: 10.1016/j.jhazmat.2021.127539
- Ge M, Zhou S, Li D, Song D, Yang S, Xu M. Reduction of selenite to selenium nanoparticles by highly selenite-tolerant bacteria isolated from seleniferous soil. J Hazard Mater. 2024;472:134491. doi: 10.1016/j.jhazmat.2024.134491
- Zhang Z, Asefaw BK, Xiong Y, Chen H, Tang Y. Evidence and Mechanisms of Selenate Reduction to Extracellular Elemental Selenium Nanoparticles on the Biocathode. Environ Sci Technol. 2022;56(22):16259-16270. doi: 10.1021/acs.est.2c05145
- Otsuka O, Yamashita M. Selenium recovery from wastewater using the selenate-reducing bacterium Pseudomonas stutzeri NT-I. Hydrometallurgy. 2020;197:105470. doi: 10.1016/j.hydromet.2020.105470
- Lian S, Fan S, Yang Y, Yu B, Dai C, Qu Y. Selenium nanoparticles with photocatalytic properties synthesized by residual activated sludge. Sci Total Environ. 2022;809:151163. doi: 10.1016/j.scitotenv.2021.151163
- Bravo F, Moraga R, Valenzuela C, et al. Arsenic biomineralization and selenium nanoparticles biosynthesis by Halomonas boliviensis strain H-10 isolated from thehigh-altitude Salar de Huasco salt flat (Chile). Environ Technol Innov. 2024;34:103575. doi: 10.1016/j.eti.2024.103575
- Jain R, Jordan N, Weiss S, et al. Extracellular Polymeric Substances Govern the Surface Charge of Biogenic Elemental Selenium Nanoparticles. Environ Sci Technol. 2015;49(3):1713-1720. doi: 10.1021/es5043063
- Piacenza E, Presentato A, Ferrante F, Cavallaro G, Alduina R, Chillura Martino DF. Biogenic Selenium Nanoparticles: A Fine Characterization to Unveil Their Thermodynamic Stability. Nanomaterials. 2021;11(5):1195. doi: 10.3390/nano11051195
- Fischer S, Jain R, Krause T, et al. Impact of the Microbial Origin and Active Microenvironment on the Shape of Biogenic Elemental Selenium Nanomaterials. Environ Sci Technol. 2021;55(13):9161-9171. doi: 10.1021/acs.est.0c07217
53. Srivastava N, Mukhopadhyay M. Biosynthesis and structural characterization of selenium nanoparticles mediated by Zooglea ramigera. Powder Technol. 2013;244:26-29. doi: 10.1016/j.powtec.2013.03.050
