AccScience Publishing / AJWEP / Volume 19 / Issue 3 / DOI: 10.3233/AJW220046
RESEARCH ARTICLE

Study Significance of Low Plasma Homocysteine or  Hypohomocysteinemia and Some Parameter to Syndrome  Associated with COVID-19 in Basrah City, Iraq

Mohammed Salam Salman1* Iqbal J Alassadi2 Ahmed K Alasadi2
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1 Department of Chemistry, College of Science, University of Basrah, Iraq
2 Blood Bank in Basrah, Children’s Hospital, Basrah, Iraq
AJWEP 2022, 19(3), 103–107; https://doi.org/10.3233/AJW220046
Submitted: 27 July 2021 | Revised: 17 September 2021 | Accepted: 17 September 2021 | Published: 11 May 2022
© 2022 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

The increasing interdependence between the countries of the world has led to an increase in the risks  faced by societies in general. The COVID-19 pandemic, for example, has transcended national borders, affecting  people regardless of nationality, level of education, income or gender. As for its consequences, it has affected  the most vulnerable groups. In this study, we have considered the significance of low plasma homocysteine or  hypohomocysteinemia and some parameters of the syndrome associated with COVID-19. Just as an increase in  the level of homocysteine in plasma has a negative effect on the heart and blood vessels, its decrease may put  the health of those who suffer from it at risk. Homocysteine is known to be the natural mediator of the conversion of methionine to cysteine; hence, the danger,  as the latter is necessary for the production of glutathione, taurine and sulphate. In this study, homocysteine and  some indicators of COVID-19 syndrome were examined using ELISA kit and other methods. The homocysteine  level in the serum of people who recovered from COVID-19 was found to be lower than in normal and healthy  people. Thus, it indicates that people who have been cured may suffer from hypohomocystinemia. We also study  some parameters, such as ALP, GOT, GPT, Glucose level and HDL, cholesterol. The results showed a significant  decrease in the level of GOT enzyme and HDL level

Keywords
COVID-19
hypohomocysteinemia
ALP
GPT
GOT
HDL
Conflict of interest
The authors declare they have no competing interests
References

Centers for Disease Control and Prevention. Interim Clinical  Guidance for Management of Patients with Confirmed  2019 Novel Coronavirus (2019-nCoV) Infection, Updated  February 12, 2020. https://www.cdc.gov/coronavirus/2019- ncov/hcp/clinical-guidance-managementpatients.html  (Accessed on March 26, 2020).

Carroll, M.D., Kit, B.K. and D.A. Lacher (2012). Total and  high-density lipoprotein cholesterol in adults, 2009–2010.  NCHS data brief no 92. Hyattsville, MD: National Center  for Health Statistics; 2012

Fan, Z., Chen, L., Li, J., et al. (2020). Clinical features of  COVID-19-related liver damage. Clinical Gastroenterology  and Hepatology, 18(7): 1561-1566.

Ganguly, P. and S.F. Alam (2015) Role of homocysteine in  the development of cardiovascular disease. USA. Nutrition  Journal, 14: 6.

Hui, D.S., Azhar, I.E., Madani, T.A., Ntoumi, F., Kock,  R., Dar, O., Ippolito, G., Mchugh, T.D., Memish,  Z.A., Drosten, C., Zumla, A. and E. Petersen (2020).  The continuing 2019-nCoV epidemic threat of novel  coronaviruses to global health—The latest 2019 novel  coronavirus outbreak in Wuhan, China. Int. J. Infect.  Dis., 91: 264-266. doi:10.1016/j.ijid.2020.01.009. PMID  31953166

Jakubowski, H. (2009). The pathophysiological hypothesis  of homocysteine thiolactone-mediated vascular disease.  J Physiol Pharmacol., 59(Suppl 9): 155-167.

Jin, Y.H., Cai, L., Cheng, Z.S., Cheng, H., Deng, T., Fan, Y.P.,  et al. (2020). A rapid advice guideline for the diagnosis  and treatment of 2019 novel coronavirus (2019-nCoV)  infected pneumonia (standard version). Military Medical  Research, 7(1): 4. doi:10.1186/s40779- 020-0233-6. PMC  7003341. PMID 32029004

Jung, Y.S., Kwak, H.E., Choi, K.H. and Y.C. Kim (2003).  Effect of acute ethanol administration on S-amino acid  metabolism: Increased utilization of cysteine for synthesis  of taurine rather than glutathione. Adv. Exp. Med. Biol.,  526: 245-252.

Kalantar-Zadeh, K., Block, G., Humphreys, M.H., McAllister,  C.J. and J.D. Kopple (2004). A low, rather than a high,  total plasma homocysteine is an indicator of poor outcome  in hemodialysis patients. J Am Soc Nephrol, 15: 442-453

Kalantar-Zadeh, K. (2005). Recent advances in understanding  the malnutritioninflammation-cachexia syndrome in  chronic kidney disease patients: What is next? Semin.  Dial., 18(5): 365-369.

Liu, L. and C.D. Klaassen (1996). Different mechanism of  saturation of acetaminophen sulfate conjugation in mice  and rats. Toxicol Appl Pharmacol., 139(1): 128-134.

McCully, K.S. (2001). The biomedical significance of  homocysteine. J Sci Explor, 15: 5-20.

McCully, K.S. (2007). Homocysteine, vitamins, and vascular  disease prevention. Am J Clin Nutr., 86: 1563-1568.

National Institutes of Health (2020). New coronavirus stable  for hours on surfaces, Accessed on 17 March 2020.  Retrieved 25 March 2020

 Report of the WHO-China Joint Mission on Coronavirus  Disease 2019 (COVID-2019). (February 16-24, 2020).  http://www.who.int/docs/default-source/coronaviruse/whochina-jointmission-on-covid-19-final-report.pdf (Accessed  on March 25, 2020).

SEOM (Sociedad Española de Oncología Médica) (2020).  Las cifras del cáncer en España2020.https://seom.org/seomcms/images/stories/recursos/Cifras_del_cancer_2020

Santoli, J.M., Lindley, M.C., DeSilva, M.B., Kharbanda,  E.O., Daley, M.F., Galloway, L., Julianne, G., et al.  (2020). Effects of the COVID-19 pandemic on routine  pediatric vaccine ordering and administration — the  United States, 2020. MMWR. Morbidity and Mortality  Weekly Report, 69(19): 591593. https://doi.org/10.15585/ mmwr.mm6919e2

Satyanarayana U. and U. Chakrapani (2006). In: Biochemistry.  3rd ed. Kolkata (India): Books and Allied (P) Ltd. p. 360- 361.

Vitvitsky, V., Mosharov, E., Tritt, M., Ataullakhanov, F. and  R. Banerjee (2003). Redox regulation of homocysteinedependent glutathione synthesis. Redox Rep., 8(1): 57-63.  

Worldometer (2020). COVID-19 Coronavirus Pandemic,  2020 Available at: https://www.worldometers.info/ coronavirus/ Accessed on: 2020 March 29

Xu, Z., Shi, L., Wang, Y., Zhang, J., Huang, L., Zhang, C.,  Liu, S., Zhao, P., Liu, H., Zhu, L., Tai, Y., Bai, C., Gao,  T., Song, J., Xia, P., Dong, J., Zhao, J. and F.S. Wang  (2020). Pathological findings of COVID-19 associated  with acute respiratory distress syndrome. Lancet Respir  Med., 8: 420-422.

Zhang, C., Shi, L. and F.S. Wang (2020). Liver injury in  COVID-19: Management and challenges. The Lancet Gastroenterology & Hepatology, 5(5): 428-430

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Asian Journal of Water, Environment and Pollution, Electronic ISSN: 1875-8568 Print ISSN: 0972-9860, Published by AccScience Publishing