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Inflammatory disease of the orbit: A case series

Meliani Kaoutar1* Rhandour Widad1 Bouardi Nizar2 Maaroufi Mustapha2 Khammar Zineb1† Berrady Rhizlane1†*
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1 Department of Internal Medicine and Onco Hematology, CHU Hassan II Fez, Fez, Morocco
2 Department of Radiology, Chu Hassan II Fez, Fez, Morocco
Tumor Discovery 2024, 3(1), 1792
Submitted: 11 September 2023 | Accepted: 28 December 2023 | Published: 28 March 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( )

Inflammatory orbital pseudotumors are a heterogeneous group of diseases characterized by their sensitivity to corticosteroid treatment regardless of the underlying etiology. Histological examination is generally performed following a lack of response to steroids, progressive neurological involvement, or suspicion of malignancy on radiological imaging. Herein, we report three clinical cases presented to our internal medicine department. The first case underscores the need for enucleation of the orbit due to the aggressiveness of orbital pseudotumors. This first case revealed Takayasu disease in a 39-year-old patient. Following the failure of corticosteroid therapy, favorable progression was achieved with adalimumab. Our second case concerns a 49-year-old woman presenting with exophthalmos, demonstrating rapid improvement in both clinical and biological parameters on corticosteroid administration. However, despite clinical amelioration, the partial radiological persistence of the orbital tumor prompted a positron emission tomography scan, revealing intense metabolic activity in the orbit despite the absence of clinical symptoms. Given the impracticability of biopsy, treatment with anti-CD20 was proposed, yielding a favorable radiological response. The third case describes an inflammatory orbital pseudotumor revealed by hemolytic anemia, with improved clinical and biological parameters observed over a 6-month period.

Inflammatory disease of the orbit
Orbital inflammatory syndrome
Orbital pseudotumor
Hemolytic anemia
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Conflict of interest
The authors declare that they have no competing interest.
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Tumor Discovery, Electronic ISSN: 2810-9775 Published by AccScience Publishing