News and Announcements
EDITORIAL
Organoid research: Advanced models, precision medicine, and translational medicine
Long Bai1,2,3 ,
Rui L. Reis4,5* ,
Xiaoyuan Chen6,7,8,9,10,11,12,13* ,
Jiacan Su1,2,14* ,
Changsheng Liu1,15*
Show Less
1 Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai,
China
2 National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai,
China
3 Wenzhou Institute of Shanghai University, Wenzhou, Zhejiang,
China
4 3B’s Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco,
Portugal
5 CVS/3B’s - PT Government Associate Laboratory, Braga,
Portugal
6 Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore,
Singapore
7 Department of Chemical and Biomolecular Engineering, College of Design and Engineering, National University of Singapore,
Singapore
8 Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore,
Singapore
9 Department of Pharmacy and Pharmaceutical Sciences, Faculty of Science, National University of Singapore,
Singapore
10 Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore,
Singapore
11 Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore,
Singapore
12 Theranostics Center of Excellence (TCE), Yong Loo Lin School of Medicine, National University of Singapore,
Singapore
13 Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR),
Singapore
14 Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai,
China
15 Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Center for Biomedical Materials of the Ministry of Education, East China University of Science and Technology, Shanghai,
China
Organoid research: Advanced models, precision medicine, and translational medicine
Received: 7 February 2025 | Accepted: 12 February 2025 | Published online: 14 February 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Conflict of interest
The authors declare that they have no competing interests.
References
- Rossi G, Manfrin A, Lutolf MP. Progress and potential in organoid research. Nat Rev Genet. 2018;19(11):671-687. doi: 10.1038/s41576-018-0051-9
- Clevers H. Modeling development and disease with organoids. Cell. 2016;165(7):1586-1597. doi: 10.1016/j.cell.2016.05.082
- Kratochvil MJ, Seymour AJ, Li TL, Paşca SP, Kuo CJ, Heilshorn SC. Engineered materials for organoid systems. Nat Rev Mater. 2019;4(9):606-622. doi: 10.1038/s41578-019-0129-9
- Broutier L, Mastrogiovanni G, Verstegen MM, et al. Human primary liver cancer-derived organoid cultures for disease modeling and drug screening. Nat Med. 2017;23:1424-1435. doi: 10.1038/nm.4438
- Quadrato G, Brown J, Arlotta P. The promises and challenges of human brain organoids as models of neuropsychiatric disease. Nat Med. 2016;22(11):1220-1228. doi: 10.1038/nm.4214
- Veninga V, Voest EE. Tumor organoids: Opportunities and challenges to guide precision medicine. Cancer Cell. 2021;39(9):1190-1201. doi: 10.1016/j.ccell.2021.07.020