AccScience Publishing / OR / Volume 1 / Issue 1 / DOI: 10.36922/OR025040004
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REVIEW ARTICLE

Advancing organoid development with 3D bioprinting

Wenping Ma1,2 ,  Hongxu Lu1,2* ,  Yin Xiao3,4 ,  Chengtie Wu1,2*
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1 State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, People’s Republic of China
2 Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing
3 School of Medicine and Dentistry, Griffith University, Gold Coast, Australia
4 Institute for Biomedicine and Glycomics, Griffith University, Gold Coast, Australia
OR 2025, 1(1), 025040004 https://doi.org/10.36922/OR025040004
Submitted: 11 October 2024 | Accepted: 15 December 2024 | Published: 3 March 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
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Abstract

Organoids provide more realistic in vitro models that closely mimic their corresponding tissues or organs. Three-dimensional (3D) bioprinting allows for precise control over cell distribution, arrangement, and the regulation of cell behavior and interactions, offering flexibility and repeatability. By combining 3D bioprinting with organoid culture, optimal extracellular matrix conditions can be created, better replicating the complex interactions between cells and their environment. The integration of 3D bioprinting amplifies the scalability of organoids, facilitating the development of large-scale organ models that significantly enhance research capabilities. This review explores the crucial role of 3D bioprinting in organoid development, emphasizing its contributions to improving organoid structure and functionality. We discuss how this innovative approach supports the creation of well-defined physiological microenvironments, aids in the development of functional organoids, and enables high-throughput cultivation. Furthermore, we highlight the advantages of optimizing bioprinting strategies and bioinks to advance organoid applications. In addition, we examine the importance of refining 3D bioprinting devices to enhance organoid fabrication and application. Finally, we outline strategies for leveraging 3D bioprinting to further advance organoid research and its implications for regenerative medicine and disease modeling.

Keywords
3D bioprinting
Organoid
Bioinks
Stem cells
Funding
This work was supported by the National Key Research and Development Program of China (2023YFB3810200), the National Natural Science Foundation of China (32225028 and 32130062), the Chinese Academy of Sciences (CAS) Project for Young Scientists in Basic Research (YSBR073), Joint Research Unit Plan of Chinese Academy of Sciences (121631ZYLH20240014), the Jiangsu Province Basic Research Key Program (BK20243003), the State Key Lab Director Fund (522022000195), and the Shanghai Talent Scholar Program.
Conflict of interest
Yin Xiao and Chengtie Wu are members of the Editorial Board of this journal but were not involved in the editorial and peer-review process conducted for this paper, either directly or indirectly. Separately, the other authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.
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