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REVIEW

3D bioprinting in otorhinolaryngology: from bench to clinical application

Yuming Zhang1 ,  Qian Yang1 ,  Hua Wan2 ,  Gangcai Zhu1 ,  Zian Xiao1 ,  Ying Zhang1 ,  Lanjie Lei3* ,  Shisheng Li1*
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1 Department of Otorhinolaryngology-Head and Neck Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan, China
2 Department of Otorhinolaryngology-Head and Neck Surgery, Zhuzhou 331 Hospital, Zhuzhou, Hunan, China
3 Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, China
IJB, 3006 https://doi.org/10.36922/ijb.3006
Submitted: 24 February 2024 | Accepted: 14 March 2024 | Published: 29 April 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Three-dimensional (3D) bioprinting is a promising additive manufacturing technology that uses imaging data and computer-assisted deposition of biological materials or cells to reconstruct complex 3D structures accurately. This technology has progressed rapidly, in part because of its integration across multiple disciplines and combination with other technologies for clinical applications. Advances in experimental research and clinical applications related to otorhinolaryngology have led to the development of diagnostic and treatment methods based on 3D bioprinting, including the development of tissue engineering scaffolds, biosensors, organ chips, and organoids, surgical planning, graft construction, and medical education. Additionally, otorhinolaryngologists will be better equipped to treat tissue function defects with personalized printed graft implants. It is also expected that 3D printing can be used to build ideal in vitro models in the future to help solve existing research challenges. This article briefly introduces the relevant 3D bioprinting technologies and bioinks that can be used by otorhinolaryngologists and discusses their potential applications in otorhinolaryngology.

Keywords
3D bioprinting
Otorhinolaryngology
Tissue engineering
Experimental research
Clinical application
Funding
This work was supported by the National Natural Science Foundation of China (No. 82173341) and the Natural Science Foundation of the Hunan province (No. 2021JJ40845).
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Conflict of interest
The authors declare no conflicts of interest.
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing
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